| Full text | |
| Author(s): Show less - |
Bastos, Alliny de Souza
;
Graves, Dana T.
;
de Melo Loureiro, Ana Paula
;
Rossa Junior, Carlos
;
Tfaile Corbi, Samia Cruz
;
Frizzera, Fausto
;
Scarel-Caminaga, Raquel Mantuaneli
;
Camara, Niels Olsen
;
Andriankaja, Oelisoa M.
;
Hiyane, Meire I.
;
Perez Orrico, Silvana Regina
Total Authors: 11
|
| Document type: | Journal article |
| Source: | JOURNAL OF DIABETES AND ITS COMPLICATIONS; v. 30, n. 8, p. 1593-1599, NOV-DEC 2016. |
| Web of Science Citations: | 15 |
| Abstract | |
Background: The effect of the interaction between type 2 diabetes and dyslipidemia on inflammation and lipid peroxidation (LPO) has not been assessed. Aim: To investigate whether diabetes coupled with dyslipidemia alters oxidative metabolism leading to increased LPO products and inflammatory status. Methods: 100 patients were divided into four groups based upon diabetic and dyslipidemic status: poorly controlled diabetes with dyslipidemia (DM-PC/D), well-controlled diabetes with dyslipidemia (DM-WC/D), normoglycemic individuals with dyslipidemia (NG/D), and normoglycemic individuals without dyslipidemia (NG/ND). Plasma was evaluated for an LPO product (MDA), antioxidant levels and inflammatory cytokines. Results: Diabetics presented significantly higher levels of LPO (p < 0.05) and the DM-PC/D had higher levels of proinflammatory cytokines and MDA in the plasma in comparison with normoglycemics (p < 0.05). Interestingly IL1-beta, IL-6, and TNF-alpha in DM-WC/D were not statistically different from those in DM-PC/D. Normoglycemic individuals with dyslipidemia presented significantly increased levels of IL-6 and TNF-alpha. when compared to normoglycemic without dyslipidemia (p < 0.05). MDA levels were also positively correlated with the presence of DM complications (r = 0.42, p < 0.01). Conclusions: These findings show that dyslipidemia is associated with an increased inflammatory status, even in well-controlled diabetics and in normoglycemics. Our results suggest that lipid metabolism and peroxidation are important for the development of inflammation, which is elevated in several complications associated with diabetes. (C) 2016 Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 07/08362-8 - Correlation between lipid peroxidation and inflammatory markers profile in diabetes mellitus type 2 patients with chronic periodontal disease |
| Grantee: | Silvana Regina Perez Orrico |
| Support Opportunities: | Regular Research Grants |