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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated

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Ibarra-Soria, Ximena ; Nakahara, Thiago S. ; Lilue, Jingtao ; Jiang, Yue ; Trimmer, Casey ; Souza, Mateus A. A. ; Netto, Paulo H. M. ; Ikegami, Kentaro ; Murphy, Nicolle R. ; Kusma, Mairi ; Kirton, Andrea ; Saraiva, Luis R. ; Keane, Thomas M. ; Matsunami, Hiroaki ; Mainland, Joel ; Papes, Fabio ; Logan, Darren W.
Total Authors: 17
Document type: Journal article
Source: eLIFE; v. 6, APR 25 2017.
Web of Science Citations: 17
Abstract

The mouse olfactory sensory neuron (OSN) repertoire is composed of 10 million cells and each expresses one olfactory receptor (OR) gene from a pool of over 1000. Thus, the nose is sub-stratified into more than a thousand OSN subtypes. Here, we employ and validate an RNA-sequencing-based method to quantify the abundance of all OSN subtypes in parallel, and investigate the genetic and environmental factors that contribute to neuronal diversity. We find that the OSN subtype distribution is stereotyped in genetically identical mice, but varies extensively between different strains. Further, we identify cis-acting genetic variation as the greatest component influencing OSN composition and demonstrate independence from OR function. However, we show that olfactory stimulation with particular odorants results in modulation of dozens of OSN subtypes in a subtle but reproducible, specific and time-dependent manner. Together, these mechanisms generate a highly individualized olfactory sensory system by promoting neuronal diversity. (AU)

FAPESP's process: 09/00473-0 - Molecular biology of the olfactory system in mammals: study on the detection of odors and their neural representation in the brain
Grantee:Fabio Papes
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 15/50371-0 - Mechanisms underkying how social experience alters hormone levels, sensory signaling and behavior
Grantee:Fabio Papes
Support Opportunities: Regular Research Grants