Association between echocardiographic structural parameters and body weight in Wistar rats

Author(s)

Oliveira-Junior, Silvio A. ; Martinez, Paula F. ; Fan, William Y. C. ; Nakatani, Bruno T. ; Pagan, Luana U. ; Padovani, Carlos R. ; Cicogna, Antonio C. ; Okoshi, Marina P. ; Okoshi, Katashi

• Document type: Journal article
• Source: ONCOTARGET; v. 8, n. 16, p. 26100-26105, APR 18 2017.
• Web of Science Citations: 3

Abstract

Background: The association between echocardiographic structural parameters and body weight (BW) during rat development has been poorly addressed. We evaluated echocardiographic variables: left ventricular (LV) end-diastolic (LVDD) and end-systolic (LVSD) diameters, LV diastolic posterior wall thickness (PWT), left atrial diameter (LA), and aortic diameter (AO) in function of BW during development. Results/Materials and Methods: Male Wistar rats (n = 328, BW: 302-702 g) were retrospectively used to construct regression models and 95% confidence intervals relating to cardiac structural parameters and BW. Adjusted indexes were significant to all relationships; the regression model for predicting LVDD (R2 = 0.678; p < 0.001) and AO (R2 = 0.567; p < 0.001) had the highest prediction coefficients and LA function the lowest prediction coefficient (R2 = 0.274; p < 0.01). These relationships underwent validation by performing echocardiograms on additional rats (n = 43, BW: 300-600 g) and testing whether results were within confidence intervals of our regressions. Prediction models for AO and LA correctly allocated 38 (88.4%) and 39 rats (90.7%), respectively, within the 95% confidence intervals. Regression models for LVDD, LVSD, and PWT included 27 (62.7%), 30 (69.8%), and 19 (44.2%) animals, respectively, within the 95% confidence intervals. Conclusions: Increase in cardiac structures is associated with BW gain during rat growth. LA and AO can be correctly predicted using regression models; prediction of PWT and LV diameters is not accurate. (AU)

• FAPESP's process: 15/17539-5 - Influence of physical exercise on cardiac remodeling, oxidative stress, and signaling of MAPK and NF-kB in spontaneously hypertensive rats
• Grantee: Katashi Okoshi
• Support Opportunities: Regular Research Grants