| Full text | |
| Author(s): |
Bersanetti, Patricia A.
;
Bueno, Tatiane L. N.
;
Morandim-Giannetti, Andreia de A.
;
Nogueira, Regina F.
;
Matos, Jivaldo R.
;
Schor, Paulo
Total Authors: 6
|
| Document type: | Journal article |
| Source: | CURRENT EYE RESEARCH; v. 42, n. 4, p. 528-533, APR 2017. |
| Web of Science Citations: | 4 |
| Abstract | |
Purpose: In this study, we characterized rabbit corneas subjected to corneal cross-linking (CXL) with acai extract compared with a riboflavin photo-stimulated procedure. Materials and Methods: The corneas of the slaughterhouse rabbits were divided into three groups: control, consisting of untreated corneal samples; riboflavin/UVA, where corneas were treated with 0.1% riboflavin photo-stimulated at 365 nm as the standard protocol; and acai, where the samples were subjected to 4% acai extract for 0.5-2 h. After the CXL procedure, corneas of the three groups were characterized by analyzing their elastic modulus and thermal denaturation profile. Results: The elastic modulus at 3% strain showed an approximately threefold increase in the riboflavin/UVA group and 10.5 times in the corneas treated with 4% acai extract for 2 h, compared with the control group (p < 0.01). The denaturation temperature values of the two groups of crosslinked corneas increased significantly (p < 0.05) and were more pronounced in the acai group. Conclusions: The acai extract was effective in promoting CXL in rabbit corneas as characterized by the different techniques. (AU) | |
| FAPESP's process: | 12/07343-8 - Structural modification, physical-chemical characterization and biological testing of biomaterials and tissue for ophthalmic use |
| Grantee: | Paulo Schor |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/20857-3 - Characterization of corneas after structural modification by agents that promotes collagen crosslinking |
| Grantee: | Patrícia Alessandra Bersanetti |
| Support Opportunities: | Regular Research Grants |