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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

MATE-1 modulation by kinin B1 receptor enhances cisplatin efflux from renal cells

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Author(s):
Estrela, Gabriel R. ; Wasinski, Frederick ; Felizardo, Raphael J. F. ; Souza, Laura L. ; Camara, Niels O. S. ; Bader, Michael ; Araujo, Ronaldo C.
Total Authors: 7
Document type: Journal article
Source: Molecular and Cellular Biochemistry; v. 428, n. 1-2, p. 101-108, APR 2017.
Web of Science Citations: 4
Abstract

Cisplatin is a drug widely used in chemotherapy that frequently causes severe renal dysfunction. Organic transporters have an important role to control the absorption and excretion of cisplatin in renal cells. Deletion and blockage of kinin B1 receptor has already been show to protect against cisplatin-induced acute kidney injury. To test whether it exerts its protective function by modulating the organic transporters in kidney, we studied kinin B1 receptor knockout mice and treatment with a receptor antagonist at basal state and in presence of cisplatin. Cisplatin administration caused downregulation of renal organic transporters; in B1 receptor knockout mice, this downregulation of organic transporters in kidney was absent; and treatment by a B1 receptor antagonist attenuated the downregulation of the transporter MATE-1. Moreover, kinin B1 receptor deletion and blockage at basal state resulted in higher renal expression of MATE-1. Moreover we observed that kinin B1 receptor deletion and blockage result in less accumulation of platinum in renal tissue. Thus, we propose that B1 receptor deletion and blockage protect the kidney from cisplatin-induced acute kidney injury by upregulating the expression of MATE-1, thereby increasing the efflux of cisplatin from renal cells. (AU)

FAPESP's process: 15/20082-7 - Kallikrein kinin system in physical exercise and metabolism
Grantee:Ronaldo de Carvalho Araújo
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/06207-6 - Role of exercise and caloric restriction in cisplatin-induced acute kidney injury
Grantee:Gabriel Rufino Estrela
Support Opportunities: Scholarships in Brazil - Doctorate