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Role of exercise and caloric restriction in cisplatin-induced acute kidney injury

Grant number: 13/06207-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2014
Effective date (End): May 31, 2017
Field of knowledge:Health Sciences - Medicine
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Ronaldo de Carvalho Araújo
Grantee:Gabriel Rufino Estrela
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Cisplatin is an antitumoral agent most commonly used in chemotherapy, however nefrotoxicity limits its use. There are several mechanisms that causes renal dysfunction after cisplatin exposure: direct tubular toxicity leads to apoptosis, necrosis and inflammation. Several works with exercise shows that it is a great tool for diminishes the inflammation, apoptosis, expression of inflammatory cytokines, reactive oxygen species. Beyond augments the lifespan the caloric restriction shows to be very important to generate different kind of acute stress resistance, like in lungs, heart, kidneys and other tissues. The caloric restriction is able to augments the insulin sensivity, diminishes the inflammatory cytokines production and proteins that induce apoptosis, augments the production of anti-oxidants and anti-inflammatory proteins. In view of both exercise and caloric restriction are two great tools to attenuate the acute and chronic inflammatory process, the goal of this work is to investigate if exercise and caloric restriction individually and together may be a good alternative to prevent the cisplatin-induced acute kidney injury. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ESTRELA, GABRIEL R.; WASINSKI, FREDERICK; GREGNANI, MARCOS F.; FREITAS-LIMA, LEANDRO C.; ARRUDA, ADRIANO C.; MORAIS, RAFAEL LEITE; MALHEIROS, DENISE M. A. C.; CAMARA, NIELS O. S.; PESQUERO, JOAO BOSCO; BADER, MICHAEL; BARROS, CARLOS CASTILHO; ARAUJO, RONALDO CARVALHO. Angiotensin-Converting Enzyme Inhibitor Protects Against Cisplatin Nephrotoxicity by Modulating Kinin B1 Receptor Expression and Aminopeptidase P Activity in Mice. FRONTIERS IN MOLECULAR BIOSCIENCES, v. 7, MAY 20 2020. Web of Science Citations: 0.
ESTRELA, GABRIEL R.; WASINSKI, FREDERICK; FELIZARDO, RAPHAEL J. F.; SOUZA, LAURA L.; CAMARA, NIELS O. S.; BADER, MICHAEL; ARAUJO, RONALDO C. MATE-1 modulation by kinin B1 receptor enhances cisplatin efflux from renal cells. Molecular and Cellular Biochemistry, v. 428, n. 1-2, p. 101-108, APR 2017. Web of Science Citations: 4.
ESTRELA, GABRIEL R.; WASINSKI, FREDERICK; BATISTA, ROGERIO O.; HIYANE, MEIRE I.; FELIZARDO, RAPHAEL J. F.; CUNHA, FLAVIA; DE ALMEIDA, DANILO C.; MALHEIROS, DENISE M. A. C.; CAMARA, NIELS O. S.; BARROS, CARLOS C.; BADER, MICHAEL; ARAUJO, RONALDO C. Caloric Restriction Is More Efficient than Physical Exercise to Protect from Cisplatin Nephrotoxicity via PPAR-Alpha Activation. FRONTIERS IN PHYSIOLOGY, v. 8, MAR 2 2017. Web of Science Citations: 4.

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