| Full text | |
| Author(s): |
do Amaral-Silva, Gleyson Kleber
;
Martins, Manoela Domingues
;
Rebelo Pontes, Helder Antonio
;
Fregnani, Eduardo Rodrigues
;
Lopes, Marcio Ajudarte
;
Fonseca, Felipe Paiva
;
Vargas, Pablo Agustin
Total Authors: 7
|
| Document type: | Review article |
| Source: | JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 46, n. 4, p. 241-245, APR 2017. |
| Web of Science Citations: | 7 |
| Abstract | |
Different environmental agents may cause DNA mutations by disrupting its double-strand structure; however, even normal DNA polymerase function may synthesize mismatch nucleotide bases, occasionally demonstrating failure in its proofreading activity. To overcome this issue, mismatch repair (MMR) system, a group of proteins specialized in finding mispairing bases and small loops of insertion or deletion, works to avoid the occurrence of mutations that could ultimately lead to innumerous human diseases. In the last decades, the role of MMR proteins in oral carcinogenesis and in the development of other oral cavity neoplasms has grown, but their importance in the pathogenesis and their prognostic potential for patients affected by oral malignancies, especially oral squamous cell carcinoma (OSCC), remain unclear. Therefore, in this manuscript we aimed to review and critically discuss the currently available data on MMR proteins expression in oral potentially malignant lesions, in OSCC, and in other oral neoplasms to better understand their relevance in these lesions. (AU) | |
| FAPESP's process: | 15/16056-0 - ADENOCARCINOMA NOT OTHERWISE SPECIFIED OF SALIVARY GLANDS: HISTOPATHOLOGICAL, PROTEIC AND GENETIC STUDY |
| Grantee: | Felipe Paiva Fonseca |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 15/21520-8 - Analysis of the expression of proteins related to DNA repair, anti-apoptosis and cellular proliferation in ameloblastoma and ameloblastic carcinoma |
| Grantee: | Gleyson Kleber do Amaral Silva |
| Support Opportunities: | Scholarships in Brazil - Master |