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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Total renal denervation reduces sympathoexcitation to different target organs in a model of chronic kidney disease

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Author(s):
Veiga, Glaucia L. ; Nishi, Erika E. ; Estrela, Heder F. ; Lincevicius, Gisele S. ; Gomes, Guiomar N. ; Simoes Sato, Alex Y. ; Campos, Ruy R. ; Bergamaschi, Cassia T.
Total Authors: 8
Document type: Review article
Source: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL; v. 204, p. 81-87, MAY 2017.
Web of Science Citations: 5
Abstract

It is known that increased sympathetic nerve activity in chronic kidney disease (CKD) progressively worsens kidney function and hypertension. We tested the hypothesis that total renal denervation contributes to reduce sympathetic activation to different beds and improves renal function in 5/6 nephrectomy model of CKD in male Wistar rats. After eight weeks of 5/6 nephrectomy surgery there was an increase in mean arterial pressure (CKD 179 +/- 22 mm Hg, n = 6 vs. control animals 108 +/- 9; p < 0.05, n = 6) with no changes in heart rate (HR). Sympathetic nerve activity was increased at different levels to the remaining kidney, splanchnic and lumbar beds compared to control (CTL) group (CKD rSNA: 150 +/- 50, n = 9 vs. CTL 96 +/- 15, n = 9; CKD sSNA: 129 +/- 51, n = 5 vs. CTL 34 +/- 14, n = 6; CKD ISNA: 203 +/- 35, n = 8 vs. CTL 146 +/- 21, spikes/s, n = 7, p < 0.05). Three weeks after total renal denervation (DNX) MAP was normalized in the CKD rats (124 +/- 19 mm Hg, n = 5, p < 0.05), with no change in HR. The ISNA was normalized (151 +/- 40, n = 5, vs. CKD 203 +/- 35 spikes/s, n = 8) and sSNA was decreased in 49% (64 +/- 34, n = 5 vs. CKD 129 +/- 51 spikes/s, n = 5, p < 0.05). Renal function, assessed by creatinine plasma levels was improved after renal denervation (CKD 1.50 +/- 0.64, n = 8; vs. CKD + DNX 0.82 +/- 0.22 mg/mL, n = 8, p < 0.05). These findings demonstrate that renal nerves contribute to the maintenance of hypertension in CKD by increasing sympathoexcitation to other beds. (C) 2016 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 13/23741-6 - Evaluation of central mechanisms in the renorenal reflex and the role of afferent renal nerves in renovascular hypertension
Grantee:Erika Emy Nishi
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/22522-9 - Role of renal sympathetic nerves on cardiovascular and renal alterations in renovascular hypertension
Grantee:Ruy Ribeiro de Campos Junior
Support type: Regular Research Grants