Papillomaviruses: a systematic review

Author(s)

Araldi, Rodrigo Pinheiro ; Reis Assaf, Suely Muro ; de Carvalho, Rodrigo Franco ; Caldas Rocha de Carvalho, Marcio Augusto ; de Souza, Jacqueline Mazzuchelli ; Magnelli, Roberta Fiusa ; Modolo, Diego Grando ; Roperto, Franco Peppino ; Stocco, Rita de Cassia ; Becak, Willy

• Document type: Journal article
• Source: GENETICS AND MOLECULAR BIOLOGY; v. 40, n. 1, p. 1-21, JAN-MAR 2017.
• Web of Science Citations: 8

Abstract

Abstract In the last decades, a group of viruses has received great attention due to its relationship with cancer development and its wide distribution throughout the vertebrates: the papillomaviruses. In this article, we aim to review some of the most relevant reports concerning the use of bovines as an experimental model for studies related to papillomaviruses. Moreover, the obtained data contributes to the development of strategies against the clinical consequences of bovine papillomaviruses (BPV) that have led to drastic hazards to the herds. To overcome the problem, the vaccines that we have been developing involve recombinant DNA technology, aiming at prophylactic and therapeutic procedures. It is important to point out that these strategies can be used as models for innovative procedures against HPV, as this virus is the main causal agent of cervical cancer, the second most fatal cancer in women. (AU)

• FAPESP's process: 14/20617-5 - Study of the action of bovine papillomavirus (BPV) in epithelial-mesenchymal transition
• Grantee: Rodrigo Pinheiro Araldi
• Support Opportunities: Scholarships in Brazil - Doctorate