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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Low-sodium diet induces atherogenesis regardless of lowering blood pressure in hypertensive hyperlipidemic mice

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Fusco, Fernanda B. ; Gomes, Diego J. ; Bispo, Kely C. S. ; Toledo, Veronica P. ; Barbeiro, Denise F. ; Capelozzi, Vera L. ; Furukawa, Luzia N. S. ; Velosa, Ana P. P. ; Teodoro, Walcy R. ; Heimann, Joel C. ; Quintao, Eder C. R. ; Passarelli, Marisa ; Nakandakare, Edna R. ; Catanozi, Sergio
Total Authors: 14
Document type: Journal article
Source: PLoS One; v. 12, n. 5 MAY 8 2017.
Web of Science Citations: 0

This study investigated the influence of sodium restriction and antihypertensive drugs on atherogenesis utilizing hypertensive (H) low-density lipoprotein-receptor knockout mice treated or not with losartan (Los) or hydralazine (Hyd) and fed low-sodium (LS) or normal-sodium (NS) chow. Despite reducing the blood pressure (BP) of H-LS mice, the LS diet caused arterial lipid infiltration due to increased plasma total cholesterol (TC) and triglycerides (TG). Los and Hyd reduced the BP of H-LS mice, and Los effectively prevented arterial injury, likely by reducing plasma TG and nonesterified fatty acids. Aortic lipid infiltration was lower in Los-treated H-LS mice (H-LS+Los) than in normotensive (N)-LS and H-LS mice. Aortic angiotensin II type 1 (AT1) receptor content was greater in H-NS than H-LS mice and in H-LS+Hyd than H-LS+Los mice. Carboxymethyl-lysine (CML) and receptor for advanced glycation end products (RAGE) immunostaining was greater in H-LS than H-NS mice. CML and RAGE levels were lower in LS animals treated with antihypertensive drugs, and Hyd enhanced the AT1 receptor level. Hyd also increased the gene expression of F4/80 but not tumor necrosis factor-a, interleukin (IL)-1 beta, IL-6, IL-10, intercellular adhesion molecule-1 or cluster of differentiation 66. The novelty of the current study is that in a murine model of simultaneous hypertension and hyperlipidemia, the pleiotropic effect of chronic, severe sodium restriction elicited aortic damage even with reduced BP. These negative effects on the arterial wall were reduced by AT1 receptor antagonism, demonstrating the influence of angiotensin II in atherogenesis induced by a severely LS diet. (AU)

FAPESP's process: 11/04631-0 - Advanced glycation end-products and renin-angiotensin system: impact on the development of atherosclerosis in dislipidemic mice
Grantee:Diego Juvenal Gomes
Support type: Scholarships in Brazil - Master
FAPESP's process: 11/16164-7 - Aortic lipid infiltration in renovascular hypertensive hyperlipidemic mice elicited by dietary sodium chloride restriction improves by losartan and hydralazine
Grantee:Fernanda Bueno Fusco
Support type: Scholarships in Brazil - Master
FAPESP's process: 13/11084-0 - Chronic sodium chloride restriction and atherogenesis in animal model of dyslipidemia and hypertension
Grantee:Sergio Catanozi
Support type: Regular Research Grants
FAPESP's process: 12/19755-9 - Advanced glycation end products and renin-angiotensin system: impact on the development of atherosclerosis in dyslipidemic mice
Grantee:Marisa Passarelli
Support type: Regular Research Grants