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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A combined approach using differential scanning calorimetry with polarized light thermomicroscopy in the investigation of ketoprofen and nicotinamide cocrystal

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Perpetuo, G. L. ; Chierice, G. O. ; Ferreira, L. T. ; Fraga-Silva, T. F. C. ; Venturini, J. ; Arruda, M. S. P. ; Bannach, G. ; Castro, R. A. E.
Total Authors: 8
Document type: Journal article
Source: Thermochimica Acta; v. 651, p. 1-10, MAY 10 2017.
Web of Science Citations: 1

A screening of ketoprofen cocrystal with nicotinamide as a coformer was performed using the Kofler contact method and mechanochemistry. The crystallization of KET (with cocrystal formation) can occur during the heating process. However, although it is thermodynamically favorable, it was found that the kinetic reactions were slow, since the KET crystallization took about 30 days. The compounds obtained were analysed by differential scanning calorimetry (DSC), polarized light thermomicroscopy (PLTM), Fourier transform infrared spectroscopy (FTIR), and X-ray powder diffraction (XRPD). Cocrystal formation between ketoprofen and nicotinamide has great interest because the nicotinamide has FDA/GRAS status. At the adopted conditions, the achievement of cocrystal between ketoprofen and nicotinamide was not possible by mechanochemical methods However, experiments conducted by the Kofler method confirmed that ketoprofen interacted, under determined conditions, with nicotinamide giving rise to a new cocrystal. Furthermore, biological tests revealed that the KET+ NA (1:1) eutectic system obtained by grinding had a greater anti-inflammatory action when compared to pure ketoprofen. (C) 2017 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 12/21450-1 - Thermoanalytical studies, synthesis and characterization of the solid co-crystals of ketoprofen with some co-formers
Grantee:Gilbert Bannach
Support type: Regular Research Grants
FAPESP's process: 13/09022-7 - Thermoanalytical studies, synthesis and characterization of the solid co-crystals of antibiotics (fluoroquinolones) with some co-formers
Grantee:Massao Ionashiro
Support type: Regular Research Grants