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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Unveiling the Impact of the Genomic Architecture on the Evolution of Vertebrate microRNAs

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Author(s):
Franca, Gustavo S. ; Hinske, Ludwig C. ; Galante, Pedro A. F. ; Vibranovski, Maria D.
Total Authors: 4
Document type: Review article
Source: FRONTIERS IN GENETICS; v. 8, MAR 21 2017.
Web of Science Citations: 4
Abstract

Eukaryotic genomes frequently exhibit interdependency between transcriptional units, as evidenced by regions of high gene density. It is well recognized that vertebrate microRNAs (miRNAs) are usually embedded in those regions. Recent work has shown that the genomic context is of utmost importance to determine miRNA expression in time and space, thus affecting their evolutionary fates over long and short terms. Consequently, understanding the inter- and intraspecific changes on miRNA genomic architecture may bring novel insights on the basic cellular processes regulated by miRNAs, as well as phenotypic evolution and disease-related mechanisms. (AU)

FAPESP's process: 15/20844-4 - The role of gametogenesis on the origin and evolution of new genes
Grantee:Maria Dulcetti Vibranovski
Support Opportunities: Research Grants - Young Investigators Grants