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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Role of the locus coeruleus catecholaminergic neurons in the chemosensory control of breathing in a Parkinson's disease model

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Author(s):
Oliveira, Luiz M. ; Tuppy, Marina ; Moreira, Thiago S. ; Takakura, Ana C.
Total Authors: 4
Document type: Journal article
Source: Experimental Neurology; v. 293, p. 172-180, JUL 2017.
Web of Science Citations: 14
Abstract

A previous study has demonstrated that in the 6-hydroxydopamine (6-OHDA)-model of Parkinson's disease (PD) there is a reduction in the number of Phox2b neurons in the retrotrapezoid nucleus (RTN) and a decrease in the respiratory response to hypercapnia 40 days after PD-induction. The functional deficiency is restored 60 days after 6-0HDA injection and here we tested the hypothesis that the locus coeruleus (LC) could be a candidate to restore the breathing deficiency. Minute Ventilation (V-E) in response to hypercapnia (7% CO2) was assessed one day before, and then 40 and 60 days after bilateral 6-0HDA (24 mu g/mu L) or vehicle injections into the LC in control or PD-induced male Wistar rats. Bilateral injections of 6-0HDA decreased catecholaminergic neurons by 86% and 83% in the substantia nigra pars compacta (SNpc) and LC, respectively. As already described, in animals with lesions to the SNpc (N = 6/group), the reduction in the ventilatory response to hypercapnia was restored 60 days after PD (1257 +/- 81 vs. vehicle: 1185 +/- 49 mL/kg/min). However, in animals with PD and lesion in the LC, the ventilation was blunted (674 39 mL/kg/min). In another group of PD rats, we observed a reduction in the number of hypercapnia-induced-fos(+) cells in the RTN region (40 days: 38 +/- 3 and 60 days: 8.5 +/- 0.9 vs. vehicle 78 +/- 3 cells) and an increase in the LC (40 days: 46 +/- 4 and 60 days: 94 +/- 22 vs. vehicle 1 +/- 1 cells). Our data suggest that LC catecholaminergic neurons can be a candidate structure mediating chemoreceptor function in a model of PD. (C) 2017 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 14/22406-1 - Respiratory anatomofunctional changes observed in an experimental model of Parkinson Disease
Grantee:Ana Carolina Thomaz Takakura
Support type: Regular Research Grants
FAPESP's process: 16/23281-3 - Encephalic regions responsible for neuroplasticity observed in respiratory response induced by hypercapnia in a modelo of Parkinson´s s disease
Grantee:Ana Carolina Thomaz Takakura
Support type: Regular Research Grants
FAPESP's process: 15/23376-1 - Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity
Grantee:Thiago dos Santos Moreira
Support type: Research Projects - Thematic Grants
FAPESP's process: 15/18842-3 - Orexinergic and aminergic mechanisms in respiratory control in an animal model of Parkinsons Disease
Grantee:Luiz Marcelo Oliveira Santos
Support type: Scholarships in Brazil - Doctorate