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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neuroimmune Interactions in Schizophrenia: Focus on Vagus Nerve Stimulation and Acetylcholine the Alpha-7 nicotinic Acetylcholine Receptor

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das Gracas Corsi-Zuelli, Fabiana Maria ; Brognara, Fernanda ; da Silva Quirino, Gustavo Fernando ; Hiroki, Carlos Hiroji ; Fais, Rafael Sobrano ; Del-Ben, Cristina Marta ; Ulloa, Luis ; Salgado, Helio Cesar ; Kanashiro, Alexandre ; Loureiro, Camila Marcelino
Total Authors: 10
Document type: Review article
Source: FRONTIERS IN IMMUNOLOGY; v. 8, MAY 31 2017.
Web of Science Citations: 8

Schizophrenia is one of the most debilitating mental disorders and is aggravated by the lack of efficacious treatment. Although its etiology is unclear, epidemiological studies indicate that infection and inflammation during development induces behavioral, morphological, neurochemical, and cognitive impairments, increasing the risk of developing schizophrenia. The inflammatory hypothesis of schizophrenia is also supported by clinical studies demonstrating systemic inflammation and microglia activation in schizophrenic patients. Although elucidating the mechanism that induces this inflammatory profile remains a challenge, mounting evidence suggests that neuroimmune interactions may provide therapeutic advantages to control inflammation and hence schizophrenia. Recent studies have indicated that vagus nerve stimulation controls both peripheral and central inflammation via alpha-7 nicotinic acetylcholine receptor (alpha 7nAChR). Other findings have indicated that vagal stimulation and alpha 7nAChR-agonists can provide therapeutic advantages for neuropsychiatric disorders, such as depression and epilepsy. This review analyzes the latest results regarding: (I) the immune-to-brain pathogenesis of schizophrenia; (II) the regulation of inflammation by the autonomic nervous system in psychiatric disorders; and (III) the role of the vagus nerve and alpha 7nAChR in schizophrenia. (AU)

FAPESP's process: 12/05178-0 - Schizophrenia and other psychotic disorders: social and biological determinants
Grantee:Paulo Rossi Menezes
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/12195-9 - Impact of early life stress in the inflammatory profile of first episode of psychosis (FEP) patients and in the animal model of post-weaning social isolation
Grantee:Fabiana Maria das Graças Corsi Zuelli
Support type: Scholarships in Brazil - Master
FAPESP's process: 11/20343-4 - Antiinflammatory cholinergic pathway: the role of neuroimmunomodulation in the control of inflammatory response
Grantee:Alexandre Kanashiro
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 16/07641-0 - The NLRP3 role in erectile dysfunction in hypertensive model DOCA / salt and its possible activation by ET-1
Grantee:Rafael Sobrano Fais
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/20549-7 - New insights in cardiovascular regulation under physiological and pathophysiological condition
Grantee:Helio Cesar Salgado
Support type: Research Projects - Thematic Grants
FAPESP's process: 15/10378-6 - The role of inflammasome in the control and pathogenesis of leishmaniasis caused by Leishmania amazonensis and its relation with disease severity in resistant or susceptible hosts
Grantee:Gustavo Fernando da Silva Quirino
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/11988-5 - NLRP3 contribution to the pro-inflammatory effect of ET-1 in corpora cavernosa smooth muscle cells: relevance in erectile function.
Grantee:Fernando Silva Carneiro
Support type: Regular Research Grants