| Full text | |
| Author(s): |
Coimbra, Norberto Cysne
;
Calvo, Fabricio
;
Almada, Rafael Carvalho
;
Freitas, Renato Leonardo
;
Paschoalin-Maurin, Tatiana
;
dos Anjos-Garcia, Tayllon
;
Elias-Filho, Daoud Hibrahim
;
Ubiali, Walter Adriano
;
Lobao-Soares, Bruno
;
Tracey, Irene
Total Authors: 10
|
| Document type: | Journal article |
| Source: | Neuroscience; v. 354, p. 178-195, JUN 23 2017. |
| Web of Science Citations: | 16 |
| Abstract | |
The effects of endogenous opioid peptide antagonists on panic-related responses are controversial. Using elevated mazes and a prey-versus-predator paradigm, we investigated the involvement of the endogenous opioid peptide-mediated system in the modulation of anxiety- and panic attack-induced responses and innate fear-induced antinociception in the present work. Wistar rats were intraperitoneally pretreated with either physiological saline or naloxone at different doses and were subjected to either the elevated plus- or T-maze test or confronted by Crotalus durissus terrificus. The defensive behaviors of the rats were recorded in the presence of the predator and at 24 h after the confrontation, when the animals were placed in the experimental enclosure without the rattlesnake. The peripheral non-specific blockade of opioid receptors had a clear anxiolytic-like effect on the rats subjected to the elevated plus-maze but not on those subjected to the elevated T-maze; however, a clear panicolytic-like effect was observed, i.e., the defensive behaviors decreased, and the preyversus-predator interaction responses evoked by the presence of the rattlesnakes increased. A similar effect was noted when the rats were exposed to the experimental context in the absence of the venomous snake. After completing all tests, the naloxone-treated groups exhibited less anxiety/fear-induced antinociception than the control group, as measured by the tail-flick test. These findings demonstrate the anxiolytic and panicolytic-like effects of opioid receptor blockade. In addition, the fearlessness behavior displayed by preys treated with naloxone at higher doses enhanced the defensive behavioral responses of venomous snakes. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 03/01768-8 - Estudo neuromorfológico, neurofarmacológico e neuroetológico das respostas induzidas pelo medo e do efeito de drogas antipânico sobre o comportamento defensivo de Mesocricetus auratus em contato agressivo com Crotalus durissus terrificus (Reptilia, Viperidae) |
| Grantee: | Walter Adriano Ubiali |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 03/01794-9 - Efeito da histamina sobre os limiares de congelamento e fuga evocados por estimulacao eletrica do mesencefalo dorsal. |
| Grantee: | Nelson Ribeiro dos Santos |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 04/10173-0 - Estudo do efeito da diminuição de atividade de vias opióides sobre a expressão proteína Fos em estruturas mesencefálicas e sobre a organização do medo inato e condicionado, em um modelo de confronto entre Rattus norvegicus e Crotalus durissus terrificus |
| Grantee: | Fabricio Calvo |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 02/13307-2 - Estudo da interação entre mecanismos opióides e GABAérgicos na modulação do comportamento de defesa eliciado por estimulação elétrica e química do colículo inferior de Rattus norvegicus |
| Grantee: | Fabricio Calvo |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 02/01497-1 - Estudo do envolvimento do núcleo magno da rafe, do núcleo gigantocelular e núcleo pré-tectal anterior, e de receptores opiódes, kappa e delta serotoninérgicos 5HT2/1C, e noradrenérgicos alfa, beta, na analgesia pós-cital: um estudo neuroanatômico e neuropsicofisiológico em um modelo experimental de epilepsia |
| Grantee: | Daoud Hibrahim Elias Filho |
| Support Opportunities: | Scholarships in Brazil - Technical Training Program - Technical Training |
| FAPESP's process: | 12/03798-0 - Involvement of opioid and endocanabinoid receptors of the substantia nigra on the activity of Nigro-Tectal GABAergic pathways during defensive behaviour elicited by rodents confronted with venomous snakes |
| Grantee: | Norberto Cysne Coimbra |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 07/01174-1 - Study of the Involvement of opioid-, serotonergic- and noradrenergic-mechanisms of the pain endogenous inhibitory system in antinociceptive processes induced by oriented escape reactions evoked by chemical stimulation of the merdial hypothalamus |
| Grantee: | Norberto Cysne Coimbra |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 03/07202-6 - Estudo neuromorfológico e comportamental do efeito do tratamento crônico com paroxetina e alprazolam sobre o medo e o pânico evocado durante o confronto defensivo entre Mesocricetus auratus (Rodentia, Cricetidae) e cobra coral brasileira (Micrurus frontalis, Reptilia, Elapidae) |
| Grantee: | Tatiana Paschoalin Maurin |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 12/22681-7 - Involvement of Opioid and Endocanabinoid Receptors of the Substantia Nigra, Pars Reticulata, in the Modulation of the Activity of Nigro-Tectal GABAergic Pathways during the Organization of Defensive Behaviour of Mice Confronted with Venomous Snakes |
| Grantee: | Rafael Carvalho Almada |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |