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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An overview of carboxymethyl derivatives of chitosan: Their use as biomaterials and drug delivery systems

Full text
Author(s):
Fonseca-Santos, Bruno ; Chorilli, Marlus
Total Authors: 2
Document type: Review article
Source: Materials Science & Engineering C-Materials for Biological Applications; v. 77, p. 1349-1362, AUG 1 2017.
Web of Science Citations: 58
Abstract

Chitin is one of the most abundant natural polymers in the world and is used for the production of chitosan by deacetylation. Chitosan is nontoxic and biodegradable and, therefore, can be used as a biomaterial and for the construction of drug delivery systems. Nevertheless, the poor solubility of chitosan in neutral or alkalinized media has restricted its applications in the pharmaceutical and biomedical fields. Chitosan can be easily carboxymethylated to improve its solubility in aqueous media while its biodegradability and biocompatibility are preserved. Carboxymethyl chitosans show improved solubility in aqueous media, which makes them an attractive alternative source for producing biomaterials and drug delivery systems as well as for designing nanotechnology-based systems. Thus, carboxymethyl chitosan-based materials have a wide applicability and good potential in the development of biomedical nanodevices and controlled release drug formulations. This review summarizes preparations and properties of hydrophilic chitosan-based materials such as nanoparticles, microparticles, tablets, and films as well as procedures related to various practical applications. (C) 2017 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 15/05394-2 - Evaluating the potential of nanostructured surfactant-based systems to intranasal administration of trans-resveratrol in the optimization of Alzheimer's disease therapy
Grantee:Bruno da Fonseca dos Santos
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/24180-0 - Liquid crystalline systems as potential strategy ofr incorporation of trans-resveratrol: development, physicochemical characterization and in vitro and in vivo biological assays
Grantee:Marlus Chorilli
Support Opportunities: Regular Research Grants