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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Combining batch and continuous flow setups in the end-to-end synthesis of naturally occurring curcuminoids

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Author(s):
Carmona-Vargas, Christian C. ; Alves, Leandro de C. ; Brocksom, Timothy J. ; de Oliveira, Kleber T.
Total Authors: 4
Document type: Journal article
Source: REACTION CHEMISTRY & ENGINEERING; v. 2, n. 3, p. 366-374, JUN 2017.
Web of Science Citations: 9
Abstract

A successful end-to-end continuous flow synthesis of pure curcumin (1) and two other natural derivatives present in turmeric is described. Batch and continuous flow conditions were combined in order to develop the end-to-end process. Three operations were telescoped yielding the three different natural curcuminoids in a safe, gram-scale and reproducible manner. (AU)

FAPESP's process: 15/11801-0 - Development of flow chemistry synthetic platform to obtain molecules of pharmaceutical interest
Grantee:Leandro de Carvalho Alves
Support type: Research Grants - Innovative Research in Small Business - PIPE
FAPESP's process: 15/21110-4 - Exploiting photocatalyzed reactions under continuous flow conditions by using porphyrinoid systems: (C-FlowPhotoChem)
Grantee:Kleber Thiago de Oliveira
Support type: Regular Research Grants
FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
Grantee:Vanderlei Salvador Bagnato
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 11/13993-2 - Methodologies for the synthesis of bioactive terpenes
Grantee:Timothy John Brocksom
Support type: Regular Research Grants