Combining batch and continuous flow setups in the end-to-end synthesis of naturally occurring curcuminoids

Author(s)

Carmona-Vargas, Christian C. ; Alves, Leandro de C. ; Brocksom, Timothy J. ; de Oliveira, Kleber T.

• Document type: Journal article
• Source: REACTION CHEMISTRY & ENGINEERING; v. 2, n. 3, p. 366-374, JUN 2017.
• Web of Science Citations: 9

Abstract

A successful end-to-end continuous flow synthesis of pure curcumin (1) and two other natural derivatives present in turmeric is described. Batch and continuous flow conditions were combined in order to develop the end-to-end process. Three operations were telescoped yielding the three different natural curcuminoids in a safe, gram-scale and reproducible manner. (AU)

• FAPESP's process: 11/13993-2 - Methodologies for the synthesis of bioactive terpenes
• Grantee: Timothy John Brocksom
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
• Grantee: Vanderlei Salvador Bagnato
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 15/21110-4 - Exploiting Photocatalyzed Reactions Under Continuous Flow Conditions by using Porphyrinoid Systems: (C-FlowPhotoChem)
• Grantee: Kleber Thiago de Oliveira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/11801-0 - Development of flow chemistry synthetic platform to obtain molecules of pharmaceutical interest
• Grantee: Leandro de Carvalho Alves
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE