| Full text | |
| Author(s): Show less - |
Marangoni, Valeria S.
;
Neumann, Oara
;
Henderson, Luke
;
Kaffes, Caterina C.
;
Zhang, Hui
;
Zhang, Runmin
;
Bishnoi, Sandra
;
Ayala-Orozco, Ciceron
;
Zucolotto, Valtencir
;
Bankson, James A.
;
Nordlander, Peter
;
Halas, Naomi J.
Total Authors: 12
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| Document type: | Journal article |
| Source: | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; v. 114, n. 27, p. 6960-6965, JUL 3 2017. |
| Web of Science Citations: | 29 |
| Abstract | |
Multifunctional nanoparticles for biomedical applications have shown extraordinary potential as contrast agents in various bioimaging modalities, near-IR photothermal therapy, and for light-triggered therapeutic release processes. Over the past several years, numerous studies have been performed to synthesize and enhance MRI contrast with nanoparticles. However, understanding the MRI enhancement mechanism in a multishell nanoparticle geometry, and controlling its properties, remains a challenge. To systematically examine MRI enhancement in a nanoparticle geometry, we have synthesized MRI-active Au nanomatryoshkas. These are Au coresilica layer-Au shell nanoparticles, where Gd(III) ions are encapsulated within the silica layer between the inner core and outer Au layer of the nanoparticle (Gd-NM). This multifunctional nanoparticle retains its strong near-IR Fano-resonant optical absorption properties essential for photothermal or other near-IR light-triggered therapy, while simultaneously providing increased T-1 contrast in MR imaging by concentrating Gd(III) within the nanoparticle. Measurements of Gd-NM revealed a strongly enhanced T-1 relaxivity (r(1) similar to 24 mM(-1).s(-1)) even at 4.7 T, substantially surpassing conventional Gd(III) chelating agents (r(1) similar to 3 mM(-1).s(-1) at 4.7 T) currently in clinical use. By varying the thickness of the outer gold layer of the nanoparticle, we show that the observed relaxivities are consistent with Solomon-Bloembergen-Morgan (SBM) theory, which takes into account the longer-range interactions between the encapsulated Gd(III) and the protons of the H2O molecules outside the nanoparticle. This nanoparticle complex and its MRI T-1-enhancing properties open the door for future studies on quantitative tracking of therapeutic nanoparticles in vivo, an essential step for optimizing light-induced, nanoparticle-based therapies. (AU) | |
| FAPESP's process: | 14/13645-2 - Development of cell-membrane coatings for the stealth delivery of MRI-active nanoparticles |
| Grantee: | Valeria Spolon Marangoni |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |