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Development of cell-membrane coatings for the stealth delivery of MRI-active nanoparticles

Grant number: 14/13645-2
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): August 18, 2014
Effective date (End): July 07, 2015
Field of knowledge:Physical Sciences and Mathematics - Physics - Condensed Matter Physics
Principal Investigator:Valtencir Zucolotto
Grantee:Valeria Spolon Marangoni
Supervisor: Naomi J. Halas
Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Research place: Rice University, United States  
Associated to the scholarship:12/11166-4 - Theranostic nanomaterials applied to the cancer diagnosis and treatment and nanotoxicity studies, BP.DR


The development of multifunctional nanomaterials has been shown to be the key for enhancing cancer diagnosis and therapy. Nanomatryoshkas, nanoparticles consisting of a gold core, interstitial nanoscale SiO2 layer, and a gold shell layer, are appropriated for bioimaging and treatment applications in the near-IR, where light has a maximal penetration depth in biological tissue. However, one of the main challenges in the nanomedicine today is to overcome the barriers of the immune system. In this way, the aim of the present project is the development of new multifunctional magnetic resonance imaging (MRI)-active nanomatryoshkas and their coating with natural cell-membranes to camouflage the particles in vivo. These new nanocomposites will be characterized by electron microscopy, magnetic measurements, and spectroscopic techniques and applied in photothermal therapy studies in various cell lines, including cancer cells. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARANGONI, VALERIA S.; NEUMANN, OARA; HENDERSON, LUKE; KAFFES, CATERINA C.; ZHANG, HUI; ZHANG, RUNMIN; BISHNOI, SANDRA; AYALA-OROZCO, CICERON; ZUCOLOTTO, VALTENCIR; BANKSON, JAMES A.; et al. Enhancing T-1 magnetic resonance imaging contrast with internalized gadolinium(III) in a multilayer nanoparticle. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 114, n. 27, p. 6960-6965, . (14/13645-2)
HENDERSON, LUKE; NEUMANN, OARA; KAFFES, CATERINA; ZHANG, RUNMIN; MARANGONI, VALERIA; RAVOORI, MURALI K.; KUNDRA, VIKAS; BANKSON, JAMES; NORDLANDER, PETER; HALAS, NAOMI J.. Routes to Potentially Safer T-1 Magnetic Resonance Imaging Contrast in a Compact Plasmonic Nanoparticle with Enhanced Fluorescence. ACS NANO, v. 12, n. 8, p. 8214-8223, . (14/13645-2)

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