| Full text | |
| Author(s): |
Melhado-Kimura, Vaneska
;
Annichino Bizzacchi, Joyce Maria
;
Picoli Quaino, Susan Kelly
;
Montalvao, Silmara
;
Bahamondes, Luis
;
Fernandes, Arlete
Total Authors: 6
|
| Document type: | Journal article |
| Source: | JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH; v. 43, n. 6, p. 1054-1060, JUN 2017. |
| Web of Science Citations: | 3 |
| Abstract | |
Aim: The aim of this study was to assess the effects of the injectable depot-medroxyprogesterone acetate (DMPA) contraceptive on selected blood coagulation parameters in young, healthy new users. Methods: The prospective study included 39 healthy women aged 20-39 years, with a body mass index (BMI; kg/m(2)) < 30, who were never users of DMPA, and who opted to use DMPA (21 women) or a copper intrauterine device (IUD; 18 women). The women in the two groups were matched for age (+/- 1 year) and BMI (+/- 1). Blood samples were obtained from all participants at baseline and at 6 and 12 months. Activated partial thromboplastin time, D-dimer, protein C, antithrombin, protein S, and thrombin generation test (lag time, endogenous thrombin potential, time to peak, and velocity index of thrombin generation) were analyzed. Repeated-measures analysis of variance was used to compare the groups. Results: There were no significant differences between the groups at baseline with respect to any of the parameters evaluated; however, in the DMPA group, D-dimer levels were lower and the time to peak thrombin generation was longer than in the IUD group at 12 months of evaluation. Conclusion: Lower D-dimer and longer time to peak thrombin generation in new users of DMPA suggest a positive profile against hypercoagulability. (AU) | |
| FAPESP's process: | 11/14827-9 - Evaluation of food behavior disorders, bone mineral density (BMD) and coagulation parameters in new quarterly users of contraceptive depot medroxyprogesterone acetate (DMPA) and controls in one year of follow up |
| Grantee: | Luis Guillermo Bahamondes |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/20504-9 - Clinical findings among progestin-only contraceptives' users |
| Grantee: | Luis Guillermo Bahamondes |
| Support Opportunities: | Research Projects - Thematic Grants |