Evaluation of polymorphisms of xenobiotic metabolizing genes (GSTM1, GSTT1, GSTP1 ...
Gene polymorphisms of xenobiotic-metabolizing in patients with head and neck cancer.
| Full text | |
| Author(s): Show less - |
Marcela Augusta de Souza Pinhel
[1]
;
Caroline Leiko Sado
[2]
;
Gabriela dos Santos Longo
[3]
;
Michele Lima Gregorio
[4]
;
Gisele Sousa Amorim
[5]
;
Greiciane Maria da Silva Florim
[6]
;
Camila Montoro Mazeti
[7]
;
Denise Poltronieri Martins
[8]
;
Fabio de Nazare Oliveira
[9]
;
Marcelo Arruda Nakazone
[10]
;
Waldir Antonio Tognola
[11]
;
Doroteia Rossi Silva Souza
[12]
Total Authors: 12
|
| Affiliation: Show less - | [1] FAMERP - Brasil
[2] Universidade Federal de Sao Paulo - Brasil
[3] FAMERP. Department of Neuroscience - Brasil
[4] FAMERP - Brasil
[5] FAMERP - Brasil
[6] FAMERP - Brasil
[7] FAMERP - Brasil
[8] FAMERP - Brasil
[9] FAMERP. Department of Neuroscience - Brasil
[10] FAMERP. Hospital de Base - Brasil
[11] FAMERP - Brasil
[12] FAMERP - Brasil
Total Affiliations: 12
|
| Document type: | Journal article |
| Source: | Arquivos de Neuro-Psiquiatria; v. 71, n. 8, p. 527-532, 2013-08-00. |
| Abstract | |
Genetic and environmental factors affect the pathogenesis of Parkinson's disease (PD). Genetic variants of the enzyme glutathione S-transferases (GST) may be related to the disease. This study aimed to evaluate the influence of genetic variants of GST (GSTT1/GSTM1) and their association with the exposure to environmental toxins in PD patients. We studied 254 patients with PD and 169 controls. The GSTM1/GSTT1 variants were analyzed by polymerase chain reaction. We applied the Fisher's exact test and the χ2 test for statistical analysis (p<0.05). The present and absence for GSTT1 and GSTM1 were similar in patients and controls. The null for GSTT1 and GSTM1 (0/0) and exposure to pesticides prevailed in patients (18%) compared to controls (13%, p=0.014). This study suggests the association between PD and previous exposure to pesticides, whose effect may be enhanced in combination with null for GSTT1/GSTM1. (AU) | |
| FAPESP's process: | 09/18476-6 - Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease |
| Grantee: | Caroline Leiko Sado |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |