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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Histomorphometric and ultrastructural evaluation of the mucosa of the equine small colon subjected to distention

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Author(s):
Rafael R. Faleiros [1] ; Delphim G. Macoris [2] ; Geraldo Eleno S. Alves [3] ; Carlos Henrique Câmara Saquetti [4] ; Antonio Carlos Alessi [5]
Total Authors: 5
Affiliation:
[1] Universidade Federal de Minas Gerais. Escola de Veterinária. Depto Clínica e Cirurgia Veterinárias - Brasil
[2] Unesp. FCAV. Depto Clínica e Cirurgia Veterinária - Brasil
[3] Universidade Federal de Minas Gerais. Escola de Veterinária. Depto Clínica e Cirurgia Veterinárias - Brasil
[4] UPIS Faculdades Integradas. Faculdade de Medicina Veterinária - Brasil
[5] Unesp. FCAV. Depto Patologia
Total Affiliations: 5
Document type: Journal article
Source: Pesquisa Veterinária Brasileira; v. 27, n. 9, p. 383-387, 2007-09-00.
Abstract

Recently it has been shown that experimental distention of the small colon of horses promotes reduction of microvascular circulation and inflammation of the seromuscular layer associated with neutrophil accumulation in the lungs. However this model was not sufficient to induce evident histophatological changes in the mucosal layer. The aim of this study was to evaluate the mucosa subjected to that model of small colon distention by histomorphometry and scan electronic microscopy (SEM). Sixteen horses were used. In the distended group (DG), nine of them were subjected to distention of the small colon by a surgically implanted intraluminal balloon that was inflated with a pressure of 40mm Hg during 4 hours. In the sham-operated group (SG), the balloon was implanted but not inflated. Full-thickness intestinal samples were collected before and after obstruction and after 1.5 and 12 hours of decompression. By SEM, it was observed that the mucosa turned flat and smooth after distention and returned to the wrinkled original appearance after decompression. Twelve hours after decompression the mucosa had a more irregular appearance with points of fragmentation. There was a reduction in mucosa thickness after distention, returning to basal values after decompression. Instead of the fact that there were changes in appearance and thickness, it was concluded that the mucosa could borne up the compression caused by distention returning to the original characteristics without major lesions. (AU)