H-1 and F-19 NMR in drug stress testing: the case of voriconazole

Author(s)

Barbosa, T. M. ; Morris, G. A. ; Nilsson, M. ; Rittner, R. ; Tormena, C. F.

• Document type: Journal article
• Source: RSC ADVANCES; v. 7, n. 54, p. 34000-34004, 2017.
• Web of Science Citations: 2

Abstract

Stress tests form an important part of drug development, and of subsequent accreditation. Commonly the change in chemical composition over time is determined using chromatographic methods that separate the mixture components, but when structural characterization of the degradation products is required, other methods are needed. Arguably the most powerful method for determining chemical structure information is NMR spectroscopy. Here we show that NMR alone, using a combination of simple F-19, H-1, and DOSY experiments, can characterise both structure and kinetics of an intact reaction mixture, without the need for any physical separation. (AU)

• FAPESP's process: 14/25903-6 - Molecular structure of some amino acids and dipeptides
• Grantee: Roberto Rittner Neto
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/19229-3 - Multi-way diffusion NMR data analysis applied to chemical reaction monitoring
• Grantee: Thaís Mendonça Barbosa
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 15/08541-6 - Nuclear magnetic resonance spectroscopy: beyond molecular structure assignment
• Grantee: Claudio Francisco Tormena
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 14/12776-6 - Development and application of NMR techniques to analyse complex mixtures
• Grantee: Thaís Mendonça Barbosa
• Support Opportunities: Scholarships in Brazil - Doctorate