H-1 and F-19 NMR in drug stress testing: the case ... - BV FAPESP
Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

H-1 and F-19 NMR in drug stress testing: the case of voriconazole

Full text
Author(s):
Barbosa, T. M. ; Morris, G. A. ; Nilsson, M. ; Rittner, R. ; Tormena, C. F.
Total Authors: 5
Document type: Journal article
Source: RSC ADVANCES; v. 7, n. 54, p. 34000-34004, 2017.
Web of Science Citations: 2
Abstract

Stress tests form an important part of drug development, and of subsequent accreditation. Commonly the change in chemical composition over time is determined using chromatographic methods that separate the mixture components, but when structural characterization of the degradation products is required, other methods are needed. Arguably the most powerful method for determining chemical structure information is NMR spectroscopy. Here we show that NMR alone, using a combination of simple F-19, H-1, and DOSY experiments, can characterise both structure and kinetics of an intact reaction mixture, without the need for any physical separation. (AU)

FAPESP's process: 14/25903-6 - Molecular structure of some amino acids and dipeptides
Grantee:Roberto Rittner Neto
Support Opportunities: Regular Research Grants
FAPESP's process: 15/19229-3 - Multi-way diffusion NMR data analysis applied to chemical reaction monitoring
Grantee:Thaís Mendonça Barbosa
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 15/08541-6 - Nuclear magnetic resonance spectroscopy: beyond molecular structure assignment
Grantee:Claudio Francisco Tormena
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 14/12776-6 - Development and application of NMR techniques to analyse complex mixtures
Grantee:Thaís Mendonça Barbosa
Support Opportunities: Scholarships in Brazil - Doctorate