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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chemical constituents and antileukemic activity of Eugenia dysenterica

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Vitek, Renan ; de Novais, Leice M. R. ; Torquato, Heron F. V. ; Paredes-Gamero, Edgar J. ; de Carvalho, Mario G. ; de Sousa, Jr., Paulo T. ; Jacinto, Marcos J. ; da Silva, Virginia C.
Total Authors: 8
Document type: Journal article
Source: NATURAL PRODUCT RESEARCH; v. 31, n. 16, p. 1930-1934, 2017.
Web of Science Citations: 1

The study about Eugenia dysenterica led to the isolation of 3-acetyl-urs-12-en-28-oic (1), 3-acetyl-olean-12-en-28-oic acid (2) and isoquercetin (3) from the stem barks, and of 3-O--glucopyranosyl--sitosterol (4), methyl 3-hydroxy-4-methoxybenzoate (5), methyl 4-hydroxyphenyl propionate (6), E-methyl-4-hydroxycinnamate (7), quercetin-3-O-(6??-O-galloyl)--d-glucopyranoside (8) and quercetin-3-O--d-galactopyranoside (9) from the leaves. The structures 1-9 were set through the analysis of their NMR spectroscopic data. Compounds 2, 3 and 5-8 were reported for the first time in the Eugenia genus. Compound 8 reduced cell viability and presented IC50 values 40.3 and 36.7M, for the CCRF-CEM and the Kasumi-1 cells, respectively. {[}GRAPHICS] . (AU)

FAPESP's process: 15/16799-3 - Investigating the role of Intracellular Ca2+ as a modulator of leukemic and hematopoietic stem cells
Grantee:Edgar Julian Paredes-Gamero
Support type: Regular Research Grants