Chemical constituents and antileukemic activity of Eugenia dysenterica

Author(s)

Vitek, Renan ; de Novais, Leice M. R. ; Torquato, Heron F. V. ; Paredes-Gamero, Edgar J. ; de Carvalho, Mario G. ; de Sousa, Jr., Paulo T. ; Jacinto, Marcos J. ; da Silva, Virginia C.

• Document type: Journal article
• Source: NATURAL PRODUCT RESEARCH; v. 31, n. 16, p. 1930-1934, 2017.
• Web of Science Citations: 1

Abstract

The study about Eugenia dysenterica led to the isolation of 3-acetyl-urs-12-en-28-oic (1), 3-acetyl-olean-12-en-28-oic acid (2) and isoquercetin (3) from the stem barks, and of 3-O--glucopyranosyl--sitosterol (4), methyl 3-hydroxy-4-methoxybenzoate (5), methyl 4-hydroxyphenyl propionate (6), E-methyl-4-hydroxycinnamate (7), quercetin-3-O-(6??-O-galloyl)--d-glucopyranoside (8) and quercetin-3-O--d-galactopyranoside (9) from the leaves. The structures 1-9 were set through the analysis of their NMR spectroscopic data. Compounds 2, 3 and 5-8 were reported for the first time in the Eugenia genus. Compound 8 reduced cell viability and presented IC50 values 40.3 and 36.7M, for the CCRF-CEM and the Kasumi-1 cells, respectively. {[}GRAPHICS] . (AU)

• FAPESP's process: 15/16799-3 - Investigating the role of intracellular Ca2+ as a modulator of leukemic and hematopoietic stem cells
• Grantee: Edgar Julian Paredes-Gamero
• Support Opportunities: Regular Research Grants