Modulation of AMPK pathway by phenolic compounds from Brazilian fruits in L6 myocytes
| Full text | |
| Author(s): |
Vitek, Renan
;
de Novais, Leice M. R.
;
Torquato, Heron F. V.
;
Paredes-Gamero, Edgar J.
;
de Carvalho, Mario G.
;
de Sousa, Jr., Paulo T.
;
Jacinto, Marcos J.
;
da Silva, Virginia C.
Total Authors: 8
|
| Document type: | Journal article |
| Source: | NATURAL PRODUCT RESEARCH; v. 31, n. 16, p. 1930-1934, 2017. |
| Web of Science Citations: | 1 |
| Abstract | |
The study about Eugenia dysenterica led to the isolation of 3-acetyl-urs-12-en-28-oic (1), 3-acetyl-olean-12-en-28-oic acid (2) and isoquercetin (3) from the stem barks, and of 3-O--glucopyranosyl--sitosterol (4), methyl 3-hydroxy-4-methoxybenzoate (5), methyl 4-hydroxyphenyl propionate (6), E-methyl-4-hydroxycinnamate (7), quercetin-3-O-(6??-O-galloyl)--d-glucopyranoside (8) and quercetin-3-O--d-galactopyranoside (9) from the leaves. The structures 1-9 were set through the analysis of their NMR spectroscopic data. Compounds 2, 3 and 5-8 were reported for the first time in the Eugenia genus. Compound 8 reduced cell viability and presented IC50 values 40.3 and 36.7M, for the CCRF-CEM and the Kasumi-1 cells, respectively. {[}GRAPHICS] . (AU) | |
| FAPESP's process: | 15/16799-3 - Investigating the role of Intracellular Ca2+ as a modulator of leukemic and hematopoietic stem cells |
| Grantee: | Edgar Julian Paredes-Gamero |
| Support type: | Regular Research Grants |