An Aminocatalyzed Stereoselective Strategy for the Formal alpha-Propargylation of Ketones

Jurberg, Igor D.

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An Aminocatalyzed Stereoselective Strategy for the Formal alpha-Propargylation of Ketones

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Author(s):	Jurberg, Igor D. Total Authors: 1
Document type:	Journal article
Source:	CHEMISTRY-A EUROPEAN JOURNAL; v. 23, n. 41, p. 9716-9720, JUL 21 2017.
Web of Science Citations:	13
Abstract
A two-step reaction sequence is described for the asymmetric formal alpha-propargylation of ketones. This approach takes advantage of an aminocatalyzed conjugate addition of ketones to alkylidene isoxazol-5-ones, followed by a controlled nitrosative degradation event. The target compounds can be accessed in broad scope, in moderate to good yields, perfect diastereocontrol and good to excellent enantioselectivity. (AU)

FAPESP's process:	15/20809-4 - Exploring the Chemistry of Isoxazol-5-ones as Versatile Building Blocks in Organic Synthesis
Grantee:	Igor Dias Jurberg
Support Opportunities:	Regular Research Grants

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