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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation

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Santos-Almeida, Fernanda Machado ; Domingos-Souza, Gean ; Meschiari, Cesar A. ; Favaro, Laura Campos ; Becari, Christiane ; Castania, Jaci A. ; Lopes, Alexandre ; Cunha, Thiago M. ; Moraes, Davi J. A. ; Cunha, Fernando Q. ; Ulloa, Luis ; Kanashiro, Alexandre ; Tezini, Geisa C. S. V. ; Salgado, Helio C.
Total Authors: 14
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 7, JUL 24 2017.
Web of Science Citations: 3
Abstract

Recent studies demonstrated a critical functional connection between the autonomic (sympathetic and parasympathetic) nervous and the immune systems. The carotid sinus nerve (CSN) conveys electrical signals from the chemoreceptors of the carotid bifurcation to the central nervous system where the stimuli are processed to activate sympathetic and parasympathetic efferent signals. Here, we reported that chemoreflex activation via electrical CSN stimulation, in conscious rats, controls the innate immune response to lipopolysaccharide attenuating the plasma levels of inflammatory cytokines such as tumor necrosis factor (TNF), interleukin 1 beta (IL-1 beta) and interleukin 6 (IL-6). By contrast, the chemoreflex stimulation increases the plasma levels of anti-inflammatory cytokine interleukin 10 (IL-10). This chemoreflex anti-inflammatory network was abrogated by carotid chemoreceptor denervation and by pharmacological blockade of either sympathetic - propranolol - or parasympathetic -methylatropine-signals. The chemoreflex stimulation as well as the surgical and pharmacological procedures were confirmed by real-time recording of hemodynamic parameters {[}pulsatile arterial pressure (PAP) and heart rate (HR)]. These results reveal, in conscious animals, a novel mechanism of neuromodulation mediated by the carotid chemoreceptors and involving both the sympathetic and parasympathetic systems. (AU)

FAPESP's process: 11/20343-4 - Antiinflammatory cholinergic pathway: the role of neuroimmunomodulation in the control of inflammatory response
Grantee:Alexandre Kanashiro
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 13/06452-0 - Cardiovascular regulation in mice with attenuation or overexpression of the gene of vesicular acetylcholine transporter (VAChT): parasympathetic function in heart failure
Grantee:Geisa Cristina Singolani Vaccari Tezini Reis
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/26217-6 - Effect of acetylcholinesterase inhibition on connexin 43 preservation in the heart of rats with acute myocardial infarction
Grantee:Fernanda Machado Santos de Almeida
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/20549-7 - New insights in cardiovascular regulation under physiological and pathophysiological condition
Grantee:Helio Cesar Salgado
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/13269-8 - Effects of chronic electrical stimulation of carotid sinus in cardiovascular function in spontaneously hypertensive rats
Grantee:Gean Domingos da Silva Souza
Support type: Scholarships in Brazil - Doctorate