Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus-Infected Patients in Brazil

Author(s):Show less -

Kam, Yiu-Wing ; Leite, Juliana Almeida ; Lum, Fok-Moon ; Tan, Jeslin J. L. ; Lee, Bernett ; Judice, Carla C. ; de Toledo Teixeira, Daniel Augusto ; Andreata-Santos, Robert ; Vinolo, Marco A. ; Angerami, Rodrigo ; Resende, Mariangela Ribeiro ; Ribas Freitas, Andre Ricardo ; Amaral, Eliana ; Passini Junior, Renato ; Costa, Maria Laura ; Guida, Jose Paulo ; Arns, Clarice Weis ; Ferreira, Luis Carlos S. ; Nia, Laurent R. ; Proenca-Modena, Jose Luiz ; Ng, Lisa F. P. ; Costa, Fabio T. M. ; Network, Zika-Unicamp

• Document type: Journal article
• Source: Journal of Infectious Diseases; v. 216, n. 2, p. 172-181, JUL 15 2017.
• Web of Science Citations: 26

Abstract

Background. Zika virus (ZIKV) infections have been linked to different levels of clinical outcomes, ranging from mild rash and fever to severe neurological complications and congenital malformations. Methods. We investigated the clinical and immunological response, focusing on the immune mediators profile in 95 acute ZIKV-infected adult patients from Campinas, Brazil. These patients included 6 pregnant women who later delivered during the course of this study. Clinical observations were recorded during hospitalization. Levels of 45 immune mediators were quantified using multiplex microbead-based immunoassays. Results. Whereas 11.6% of patients had neurological complications, 88.4% displayed mild disease of rash and fever. Several immune mediators were specifically higher in ZIKV-infected patients, and levels of interleukin 10, interferon gamma-induced protein 10 (IP-10), and hepatocyte growth factor differentiated between patients with or without neurological complications. Interestingly, higher levels of interleukin 22, monocyte chemoattractant protein 1, TNF-alpha, and IP-10 were observed in ZIKV-infected pregnant women carrying fetuses with fetal growth-associated malformations. Notably, infants with congenital central nervous system deformities had significantly higher levels of interleukin 18 and IP-10 but lower levels of hepatocyte growth factor than those without such abnormalities born to ZIKV-infected mothers. Conclusions. This study identified several key markers for the control of ZIKV pathogenesis. This will allow a better understanding of the molecular mechanisms of ZIKV infection in patients. (AU)

• FAPESP's process: 16/00194-8 - Pathogenesis and neurovirulence of emerging viruses in Brazil
• Grantee: José Luiz Proença Módena
• Support Opportunities: Research Grants - Young Investigators Grants