Skin changes in streptozotocin-induced diabetic rats

Author(s)

Moretti Andrade, Thiago Antonio ; Masson-Meyers, Daniela Santos ; Caetano, Guilherme Ferreira ; Terra, Vania Aparecida ; Ovidio, Paula Payao ; Jordao-Junior, Alceu Afonso ; Cipriani Frade, Marco Andrey

• Document type: Journal article
• Source: Biochemical and Biophysical Research Communications; v. 490, n. 4, p. 1154-1161, SEP 2 2017.
• Web of Science Citations: 4

Abstract

Diabetes can cause serious health complications, which can affect every organ of the body, including the skin. The molecular etiology has not yet been clarified for all diabetic skin conditions. Thus, this study aimed to investigate the changes of diabetes in skin compared to non-diabetic skin in rats. Fifteen days after establishing the diabetic status, skin samples from the dorsum-cervical region were harvested for subsequent analysis of alterations caused by diabetes. Our results demonstrate that diabetes stimulated higher inflammation and oxidative stress in skin, but antioxidant defense levels were lower compared to the non-diabetic group (p < 0.05). This could have been related to a decreased number of blood vessels and low expression of VEGF, eNOS and TGF-beta 1. Finally, insulin signaling proteins IRS, Akt, Shc and ERK showed a low expression in the diabetic group. Thus, our study shows that the pathology of diabetes induced immunohistopathological and biochemical skin changes compared to non-diabetic skin in rats. (C) 2017 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 09/09355-0 - Activity of natural latex biomembrane of Hevea brasiliensis rubber tree and oncostatin M on wound healing in diabetic rats
• Grantee: Marco Andrey Cipriani Frade
• Support Opportunities: Regular Research Grants