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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Can anxiety increase tremors in patients with Parkinson’s disease? An experimental model

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Author(s):
Marcos Hortes N. Chagas ; Taís Helena G. F. Oliveira [2] ; Ila M. P. Linares [3] ; Fernanda B. Balarini [4] ; Natalia Mota S. Chagas [5] ; Vitor Tumas [6] ; José Alexandre S. Crippa [7]
Total Authors: 7
Document type: Journal article
Source: ARCHIVES OF CLINICAL PSYCHIATRY; v. 44, n. 4, p. 85-88, 2017-08-00.
Abstract

Abstract Background Among non-motor symptoms of Parkinson’s disease (PD), anxiety occurs in up to 67% of patients. Clinically, PD patients report worsening of tremors in anxiogenic situations. Objective The aim of this study was to evaluate the association between motor symptoms and anxiety in PD patients and compare their performances with those of healthy volunteers. Methods Fifteen volunteers with PD and 15 healthy volunteers without clinically significant psychiatric disorders were evaluated. Both groups were subjected to a simulated public speaking test (SPST). The following parameters were measured: visual analog mood scale (VAMS), items related to tremors of UPDRS, bradykinesia tests, blood pressure, and heart rate. Results Results of repeated measures ANOVA indicated a significant effect on group × phase interaction (F3.7,105.6 = 2.56; p = 0.046) for VAMS anxiety factor. Regarding tremors, ANOVA indicated significant differences in group × phase interaction (F4.5,121 = 2.88; p = 0.021) and between the groups (F1,27 = 45.88, p < 0.001), with differences in the anticipatory phase, performance, and post-speech, compared with those in the baseline. There were no significant differences between the groups with regard to other factors of VAMS, physiological measurements, and bradykinesia. Discussion Worsening of tremors occurred during SPST, particularly in phases with higher anxiety scores. (AU)

FAPESP's process: 12/10483-6 - Correlation between anxiety levels and motor symptoms in pacients with Parkinsons Disease, applying the test of simulation of public speech
Grantee:Taís Helena Garcia Fernandes de Oliveira
Support Opportunities: Scholarships in Brazil - Scientific Initiation