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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genetic variants in gastric cancer: Risks and clinical implications

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Author(s):
Gigek, Carolina Oliveira ; Calcagno, Danielle Queiroz ; Rasmussen, Lucas Trevizani ; Santos, Leonardo Caires ; Leal, Mariana Ferreira ; Wisnieski, Fernanda ; Burbano, Rommel Rodriguez ; Lourenco, Laercio Gomes ; Lopes-Filho, Gaspar Jesus ; Cardoso Smith, Marilia Arruda
Total Authors: 10
Document type: Review article
Source: Experimental and Molecular Pathology; v. 103, n. 1, p. 101-111, AUG 2017.
Web of Science Citations: 14
Abstract

Cancer is a multifactorial disease that involves many molecular alterations. Gastric cancer (GC) is the third leading cause of cancer death worldwide. GC is a highly heterogeneous disease with different molecular and genetics features. Therefore, this review focuses on an overview of the genetic aspects of gastric cancer by highlighting the important impact and role of deletions and/or duplications of chromosomal segments, genomic variants, H. pylori infection and interleukin variants, as found in gene expression and newly proposed molecular classification studies. The challenge is to better understand the mechanisms and different pathways that lead to the development and progression of GC. (AU)

FAPESP's process: 16/19953-6 - Epigenetically modulated genes may constitute therapeutic targets in patients with gastric cancer?
Grantee:Fernanda Wisnieski
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/22548-2 - Nontraumatic orthopedic conditions of shoulder: genetic and molecular aspects
Grantee:Mariana Ferreira Leal
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 12/14768-5 - Nontraumatic orthopedic conditions of shoulder: genetic and molecular aspects
Grantee:Mariana Ferreira Leal
Support type: Scholarships in Brazil - Young Researchers