Genetic variants in gastric cancer: Risks and clinical implications

Author(s)

Gigek, Carolina Oliveira ; Calcagno, Danielle Queiroz ; Rasmussen, Lucas Trevizani ; Santos, Leonardo Caires ; Leal, Mariana Ferreira ; Wisnieski, Fernanda ; Burbano, Rommel Rodriguez ; Lourenco, Laercio Gomes ; Lopes-Filho, Gaspar Jesus ; Cardoso Smith, Marilia Arruda

• Document type: Review article
• Source: Experimental and Molecular Pathology; v. 103, n. 1, p. 101-111, AUG 2017.
• Web of Science Citations: 14

Abstract

Cancer is a multifactorial disease that involves many molecular alterations. Gastric cancer (GC) is the third leading cause of cancer death worldwide. GC is a highly heterogeneous disease with different molecular and genetics features. Therefore, this review focuses on an overview of the genetic aspects of gastric cancer by highlighting the important impact and role of deletions and/or duplications of chromosomal segments, genomic variants, H. pylori infection and interleukin variants, as found in gene expression and newly proposed molecular classification studies. The challenge is to better understand the mechanisms and different pathways that lead to the development and progression of GC. (AU)

• FAPESP's process: 12/14768-5 - Nontraumatic orthopedic conditions of shoulder: genetic and molecular aspects
• Grantee: Mariana Ferreira Leal
• Support Opportunities: Scholarships in Brazil - Young Researchers
• FAPESP's process: 11/22548-2 - Nontraumatic orthopedic conditions of shoulder: genetic and molecular aspects
• Grantee: Mariana Ferreira Leal
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 16/19953-6 - Epigenetically modulated genes may constitute therapeutic targets in patients with gastric cancer?
• Grantee: Fernanda Wisnieski
• Support Opportunities: Scholarships in Brazil - Post-Doctoral