Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial

Author(s)

Borges, Ivan ; Faveri, Marcelo ; Figueiredo, Luciene Cristina ; Duarte, Poliana Mendes ; Retamal-Valdes, Belen ; Lira Montenegro, Sheyla Christinne ; Feres, Magda

• Document type: Journal article
• Source: JOURNAL OF CLINICAL PERIODONTOLOGY; v. 44, n. 8, p. 822-832, AUG 2017.
• Web of Science Citations: 6

Abstract

AimTo evaluate the clinical effects of different dosages of metronidazole (MTZ) and durations of MTZ+amoxicillin (AMX) in the treatment of generalized chronic periodontitis (GChP). Material and MethodsSubjects with severe GChP were randomly assigned to receive scaling and root planing (SRP)-only, or combined with 250 or 400mg of MTZ+AMX (500mg) thrice a day (TID), for 7 or 14days. Subjects were monitored for 1year. ResultsOne hundred and nine subjects were enrolled. At 1 year, 61.9% and 63.6% of the subjects receiving AMX+250 or 400mg of MTZ for 14days, respectively, reached the clinical endpoint for treatment (4 sites with probing depth 5mm), against 31.8% of those taking 250 or 400mg of MTZ for 7days (p<.05) and 13.6% of those receiving SRP-only (p<.05). Fourteen days of MTZ+AMX was the only significant predictor of subjects reaching the clinical endpoint at 1year (OR, 5.26; 95% CI, 2.3-12.1, p = .0000). The frequency of adverse events did not differ among treatment groups (p>.05). ConclusionThe adjunctive use of 400 or 250mg of MTZ plus 500mg of AMX/TID/14days offers statistically significant and clinically relevant benefits over those achieved with SRP alone in the treatment of severe GChP. The added benefits of the 7-days regimen in this population were less evident. (ClinicalTrials.gov NCT02735395). (AU)

• FAPESP's process: 09/17677-8 - Clinical and microbiological influence of the dose and duration of systemic antibiotics in the treatment of chronic periodontitis.
• Grantee: Magda Feres Figueiredo
• Support Opportunities: Regular Research Grants