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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of acute blood pressure elevation on biochemical-metabolic parameters in individuals with hypertensive crisis

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Author(s):
Andrade, Days Oliveira ; Santos, Sara Patricia O. ; Pinhel, Marcela Augusta S. ; Valente, Flavia Mariana ; Giannini, Marcela Cavichiolo ; Gregorio, Michele Lima ; De Godoy, Moacir Fernandes ; Souza, Doroteia Rossi S. ; Vilela-Martin, Jose Fernando
Total Authors: 9
Document type: Journal article
Source: CLINICAL AND EXPERIMENTAL HYPERTENSION; v. 39, n. 6, p. 553-561, 2017.
Web of Science Citations: 1
Abstract

Hypertensive crisis is a common clinical situation that presents a high rate of morbidity and mortality and it is characterized by symptomatic rise of blood pressure (BP), systolic (SBP) >= 180 mmHg and/or diastolic (DBP) >= 120 mmHg. It is classified as emergency (HE) or hypertensive urgency (HU). There is no description of laboratory findings in patients who present acute BP elevation. Thus, this study had the objective to assess the biochemical-metabolic parameters of patients with HC. We studied 74 normotensive individuals (NT) 74 controlled hypertensive patients (ContrHT), 50 subjects with HU, and 78 with HE for evaluating biochemical-metabolic parameters. HE Occurs in older individuals and more frequently in those with known hypertension. More patients with HE had dyslipidemia than those with HU (58% vs. 38%). The diastolic BP and heart rate were higher in the HE group (120 mmHg and 87 bpm) compared to ContrHT (71 mmHg and 71 bpm; p < 0.0001) and NT groups (75 mmHg and 68 bpm; p < 0.0001). Glycemia was higher in HE vs. NT and ContrHT (p < 0.05). HDL cholesterol was lower in HE than NT (p = 0.0088). Potassium was lower in HE vs. NT, ContrHT and HU groups (p < 0.05). Creatinine was higher in the HC group vs. NT and ContrHT (p < 0.05). The GFR was significantly lower in HE group vs. HU, ContrHT and NT (p < 0.001). In conclusion, individuals with HC show biochemical alterations when compared to ContrHT and NT. Acute BP elevations are associated with hyperglycemia, dyslipidemia, and higher potassium and creatinine levels and lower renal function. (AU)

FAPESP's process: 13/09868-3 - Proinflammatory cytokines, C-reactive protein and participation of renin-angiotensin system in patients with hypertensive crisis
Grantee:José Fernando Vilela Martin
Support Opportunities: Regular Research Grants