Regulatory T-Cell Distribution within Lung Compartments in COPD

Author(s):Show less -

Sales, Davi S. ; Ito, Juliana T. ; Zanchetta, Ivy A. ; Annoni, Raquel ; Aun, Marcelo V. ; Ferraz, Luiz Fernando S. ; Cervilha, Daniela A. B. ; Negri, Elnara ; Mauad, Thais ; Martins, Milton A. ; Lopes, Fernanda D. T. Q. S.

• Document type: Journal article
• Source: COPD-Journal of Chronic Obstructive Pulmonary Disease; v. 14, n. 5, p. 533-542, 2017.
• Web of Science Citations: 9

Abstract

The importance of the adaptive immune response, specifically the role of regulatory T (Treg) cells in controlling the obstruction progression in smokers, has been highlighted. To quantify the adaptive immune cells in different lung compartments, we used lung tissues from 21 never-smokers without lung disease, 22 current and/or ex-smokers without lung disease (NOS) and 13 current and/or ex-smokers with chronic obstructive pulmonary disease (COPD) for histological analysis. We observed increased T, B, IL-17 and BAFF(+) cells in small and large airways of COPD individuals; however, in the NOS, we only observed increase in T and IL-17(+) cells only in small airways. A decrease in the density of Treg(+), TGF-beta(+) and IL-10(+) in small and large airways was observed only in COPD individuals. In the lymphoid tissues, Treg, T,B-cells and BAFF(+) cells were also increased in COPD; however, changes in Treg inhibitory associated cytokineswere not observed in this compartment. Therefore, our results suggest that difference in Treg(+) cell distributions in lung compartments and the decrease in TGF-beta(+) and IL-10(+) cells in the airways may lead to the obstruction in smokers. (AU)

• FAPESP's process: 14/15819-8 - The respiratory epithelium as a immune response mediator in COPD pathogenesis
• Grantee: Fernanda Degobbi Tenorio Quirino dos Santos Lopes
• Support Opportunities: Regular Research Grants