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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Preferential Mitochondrial Localization of a Goniothalamin Fluorescent Derivative

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Author(s):
Raitz, Ismael ; de Souza Filho, Roberto Y. ; de Andrade, Lorena P. ; Correa, Jose R. ; Neto, Brenno A. D. ; Pilli, Ronaldo A.
Total Authors: 6
Document type: Journal article
Source: ACS OMEGA; v. 2, n. 7, p. 3774-3784, JUL 2017.
Web of Science Citations: 3
Abstract

A fluorescent 2,1,3-benzothiadiazole- containing goniothalamin derivative, BTD-GTN (1), has been synthesized and successfully tested in bioimaging experiments in live cells. The fluorescent compound proved to be capable of transposing the cell membranes, indicating its subcellular localization. The use of the benzothiadiazole core as the fluorophore revealed the favored localization of the GTN analogue 1 in the cytoplasm of live cells, preferentially in the mitochondria, in line with previous results that indicated the loss of mitochondrial transmembrane potential upon treatment with GTN. The results described herein highlight the potential of the BTD-GTN hybrid structures for future studies regarding the cellular mechanism of action of this family of compounds. (AU)

FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
Grantee:Licio Augusto Velloso
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 16/12541-4 - A biomimetic approach to the total synthesis of Stemona alkaloids
Grantee:Ronaldo Aloise Pilli
Support type: Regular Research Grants
FAPESP's process: 09/51602-5 - Chemical biology: new natural and synthetic molecular targets against cancer, structural studies, biological evaluation and mode of action
Grantee:Ronaldo Aloise Pilli
Support type: Research Projects - Thematic Grants