| Full text | |
| Author(s): Show less - |
do Amaral-Silva, Gleyson Kleber
;
Sanchez-Romero, Celeste
;
Wagner, Vivian Petersen
;
Martins, Manoela Domingues
;
Rebelo Pontes, Helder Antonio
;
Fregnani, Eduardo Rodrigues
;
Soares, Fernando Augusto
;
de Almeida, Oslei Paes
;
Rocha, Andre Caroli
;
Santos-Silva, Alan Roger
;
Fonseca, Felipe Paiva
;
Vargas, Pablo Agustin
Total Authors: 12
|
| Document type: | Journal article |
| Source: | ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 124, n. 3, p. 286-295, SEP 2017. |
| Web of Science Citations: | 0 |
| Abstract | |
Objective. The aim of this study was to investigate hMutS proteins in developing human tooth, ameloblastomas, and ameloblastic carcinoma and to determine whether the expression of these proteins has any prognostic potential. Study Design. Ten cases of developing human tooth, 39 ameloblastomas, and 2 ameloblastic carcinomas were used to determine the distribution of the proteins during the process of carcinogenesis. Simultaneously, another sample of 73 ameloblastomas was arranged in tissue microarray, and their clinical, microscopic, and radiographic features; treatment outcome; presence of BRAF-V600E mutation; and follow-up data were assessed to determine the prognostic relevance of the expression of hMutS (hMSH2, hMSH3, hMSH6) and Ki-67. hMSH2 and hMSH6 were significantly downexpressed in ameloblastomas (P = .0059) compared with developing human tooth (P <.0001). Results. hMSH2, hMSH3 expression were significantly associated with BRAF-V600E mutation (P <.05). Simultaneous overexpression of hMutS was associated with recurrence (P =.035); however, these did not predict the disease-free survival of patients (P >.05). Conclusions. hMutS proteins are downregulated in ameloblastoma; moreover, simultaneous overexpression of these proteins in ameloblastoma was associated with recurrence but did not predict disease-free survival. (AU) | |
| FAPESP's process: | 15/21520-8 - Analysis of the expression of proteins related to DNA repair, anti-apoptosis and cellular proliferation in ameloblastoma and ameloblastic carcinoma |
| Grantee: | Gleyson Kleber do Amaral Silva |
| Support Opportunities: | Scholarships in Brazil - Master |