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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Comparative proteomics reveals recruitment patterns of some protein families in the venoms of Cnidaria

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Author(s):
Jaimes-Becerra, Adrian ; Chung, Ray ; Morandini, Andre C. ; Weston, Andrew J. ; Padilla, Gabriel ; Gacesa, Ranko ; Ward, Malcolm ; Long, Paul F. ; Marques, Antonio C.
Total Authors: 9
Document type: Journal article
Source: Toxicon; v. 137, p. 19-26, OCT 2017.
Web of Science Citations: 5
Abstract

Cnidarians are probably the oldest group of animals to be venomous, yet our current picture of cnidarian venom evolution is highly imbalanced due to limited taxon sampling. High-throughput tandem mass spectrometry was used to determine venom composition of the scyphozoan Chrysaora lactea and two cubozoans Tamoya haplonema and Chiropsalmus quadrumanus. Protein recruitment patterns were then compared against 5 other cnidarian venom proteomes taken from the literature. A total of 28 putative toxin protein families were identified, many for the first time in Cnidaria. Character mapping analysis revealed that 17 toxin protein families with predominantly cytolytic biological activities were likely recruited into the cnidarian venom proteome before the lineage split between Anthozoa and Medusozoa. Thereafter, venoms of Medusozoa and Anthozoa differed during subsequent divergence of cnidarian classes. Recruitment and loss of toxin protein families did not correlate with accepted phylogenetic patterns of Cnidaria. Selective pressures that drive toxin diversification independent of taxonomic positioning have yet to be identified in Cnidaria and now warrant experimental consideration. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 10/50174-7 - Systematics, life cycle and reproductive patterns of jellyfishes (Cnidaria: Medusozoa: Cubozoa and Scyphozoa) in the Baixada Santista (São Paulo, Brazil)
Grantee:André Carrara Morandini
Support type: BIOTA-FAPESP Program - Regular Research Grants
FAPESP's process: 10/06927-0 - Biodiversity and areas of endemism of benthic hydroids (Cnidaria, Hydrozoa) from southern South America and Antarctica
Grantee:Thaís Pires Miranda
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 11/50242-5 - Dimensions of marine life: patterns and process of diversifications in planktonic and benthic cnidarians
Grantee:Antonio Carlos Marques
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 13/50484-4 - Biodiversity and distribution patterns of the Medusozoa form the South-Western Atlantic
Grantee:Antonio Carlos Marques
Support type: Regular Research Grants