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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Involvement of the prelimbic cortex in contextual fear conditioning with temporal and spatial discontinuity

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Santos, Thays Brenner ; Kramer-Soares, Juliana Carlota ; Favaro, Vanessa Manchim ; Menezes Oliveira, Maria Gabriela
Total Authors: 4
Document type: Journal article
Source: NEUROBIOLOGY OF LEARNING AND MEMORY; v. 144, p. 1-10, OCT 2017.
Web of Science Citations: 1

Time plays an important role in conditioning, it is not only possible to associate stimuli with events that overlap, as in delay fear conditioning, but it is also possible to associate stimuli that are discontinuous in time, as shown in trace conditioning for a discrete stimuli. The environment itself can be a powerful conditioned stimulus (CS) and be associated to unconditioned stimulus (US). Thus, the aim of the present study was to determine the parameters in which contextual fear conditioning occurs by the maintenance of a contextual representation over short and long time intervals. The results showed that a contextual representation can be maintained and associated after 5 s, even in the absence of a 15 s re-exposure to the training context before US delivery. The same effect was not observed with a 24 h interval of discontinuity. Furthermore, optimal conditioned response with a 5 s interval is produced only when the contexts (of pre-exposure and shock) match. As the pre-limbic cortex (PL) is necessary for the maintenance of a continuous representation of a stimulus, the involvement of the PL in this temporal and contextual processing was investigated. The reversible inactivation of the PL by muscimol infusion impaired the acquisition of contextual fear conditioning with a 5 s interval, but not with a 24 h interval, and did not impair delay fear conditioning. The data provided evidence that short and long intervals of discontinuity have different mechanisms, thus contributing to a better understanding of PL involvement in contextual fear conditioning and providing a model that considers both temporal and contextual factors in fear conditioning. (C) 2017 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 13/24576-9 - Role of the medial prefrontal cortex in contextual memories acquisition that depend on temporal processing between discontinuous stimuli
Grantee:Thays Brenner dos Santos
Support type: Scholarships in Brazil - Master