Nickel-catalysed direct C2-arylation of N-heterocyclic carbenes

Author(s)

Ho, Nga Kim T. ; Neumann, Beate ; Stammler, Hans-Georg ; Menezes da Silva, Vitor H. ; Watanabe, Daniel G. ; Braga, Ataualpa A. C. ; Ghadwal, Rajendra S.

• Document type: Journal article
• Source: DALTON TRANSACTIONS; v. 46, n. 36, p. 12027-12031, SEP 28 2017.
• Web of Science Citations: 11

Abstract

A highly efficient nickel catalysed method for the direct C2-arylation of N-heterocyclic carbenes (NHCs) is reported. This protocol enables a facile access to C2-arylated imidazolium salts (NHC-Ar)X (X = Cl, Br, I or OTf). Experimental and theoretical studies suggest the viability of a Ni(I)/Ni(II) catalytic pathway in which the dinuclear Ni(I) species {[}(NHC)NiX](2) plays a key role. (AU)

• FAPESP's process: 14/25770-6 - New frontiers in cross-coupling reactions promoted by palladium: combining enantioselective catalysis, C-H activations, new materials and in flux reactions aiming at high efficiency and sustainability in synthetic processes
• Grantee: Carlos Roque Duarte Correia
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 15/01491-3 - Theoretical study of cross-coupling reactions: homogeneous and heterogeneous catalysis
• Grantee: Ataualpa Albert Carmo Braga
• Support Opportunities: Regular Research Grants