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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Glycemic Control and Muscle Damage in 3 Athletes With Type 1 Diabetes During a Successful Performance in a Relay Ultramarathon: A Case Report

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Author(s):
Belli, Taisa [1] ; de Macedo, Denise V. [2] ; Scariot, Pedro P. M. [1] ; de Araujo, Gustavo G. [3] ; dos Reis, Ivan G. M. [1] ; Lazarim, Fernanda L. [2] ; Nunes, Lazaro A. S. [2] ; Brenzikofer, Rene [4] ; Gobatto, Claudio A. [1]
Total Authors: 9
Affiliation:
[1] Univ Estadual Campinas, Sch Appl Sci, Lab Appl Sport Physiol LAFAE, Limeira, SP - Brazil
[2] Univ Estadual Campinas, Lab Exercise Biochem LABEX, Dept Biochem, Inst Biol, Campinas, SP - Brazil
[3] Fed Univ Alagoas UFAL, Sports Sci Res Grp, Maceio, AL - Brazil
[4] Univ Estadual Campinas, Fac Phys Educ, Lab Instrumentat Biomech, Campinas, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: WILDERNESS & ENVIRONMENTAL MEDICINE; v. 28, n. 3, p. 239-245, SEP 2017.
Web of Science Citations: 5
Abstract

Ultramarathon races are fairly demanding and impose substantial physiological stress on healthy athletes. These competitions may thus be considerably more challenging for individuals with diabetes. This case study aims to describe glycemic control, muscle damage, inflammation, and renal function in 3 athletes with type 1 diabetes during a successful performance in a relay ultramarathon. The team completed the race in 29 hours and 28 minutes, earning third place. The total distance covered by each athlete was 68.7, 84.5, and 65.1 km. Most blood glucose levels showed that athletes were in a zone where it was safe to exercise (90-250 mg/dL or 5.0-13.9 mmol/L). Creatine kinase, lactate dehydrogenase, and aspartate aminotransferase serum levels increased 1.2- to 50.7-fold prerace to postrace, and were higher than the reference ranges for all the athletes postrace. Blood leukocytes, neutrophils, and serum C-reactive protein (CRP) increased 1.6-to 52-fold prerace to postrace and were higher than the reference ranges for 2 athletes after the race. Serum creatinine increased 1.2-fold prerace to postrace for all the athletes but did not meet the risk criteria for acute kidney injury. In conclusion, our main findings show evidence of satisfactory glycemic control in athletes with type 1 diabetes during a relay ultramarathon. Moreover, elevation of muscle damage and inflammatory biomarkers occurred without affecting renal function and challenging the maintenance of blood glucose among athletes. These findings are novel and provide an initial understanding of the physiological responses in athletes with type 1 diabetes during ultramarathon races. (AU)

FAPESP's process: 09/08535-5 - Standardization and validity of aerobic and anaerobic tests in field and laboratory, using free, tethered and half-tethered running, in endurance and sprint runners
Grantee:Claudio Alexandre Gobatto
Support Opportunities: Regular Research Grants