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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Analysis of differential genetic expression in endometrial polyps of postmenopausal women

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Author(s):
Troncon, J. K. [1] ; Meola, J. [1] ; Candido-dos-Reis, F. J. [1] ; Poli-Neto, O. B. [1] ; Nogueira, A. A. [1] ; Rosa-e-Silva, J. C. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Dept Obstet & Gynecol, Ribeirao Preto Med Sch, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: CLIMACTERIC; v. 20, n. 5, p. 462-466, OCT 2017.
Web of Science Citations: 1
Abstract

Objectives: To evaluate the expression of four genetic markers (PTEN, BCL2, MLH1, and CTNNB1), linked to endometrial carcinogenesis, in endometrial polyps of patients with and without postmenopausal bleeding in order to determine whether symptomatic endometrial polyps have a genetic phenotype similar to that of endometrial cancer. Methods: Samples were obtained hysteroscopically from endometrial polyps of postmenopausal patients, and the expression of genetic markers involved in the pathogenesis of endometrial cancer (PTEN, BCL2, MLH1, and CTNNB1) was analyzed. The expression of these markers was then compared between patients with and without symptoms, which was characterized as postmenopausal bleeding. Other clinical characteristics of the patients, such as duration of menopause, polyp size, presence of systemic hypertension, diabetes mellitus, and smoking habits were also analyzed. Results: Samples from a total of 60 patients were obtained, as calculated for a test power of 0.80. No statistical differences (p > 0.05) were observed between the two groups concerning the expression of the studied endometrial cancer risk factor genes, or with regard to the clinical aspects evaluated. Conclusion: The study found no evidence that symptomatic endometrial polyps have a similar phenotype to type 1 endometrial cancer; further studies are needed in order to establish whether endometrial polyps are in fact true cancer precursors, or simply raise cancer incidence due to a detection bias. (AU)

FAPESP's process: 14/20873-1 - Analysis of diferential genic expression between symptomatic and asymptomatic endometrial polyps
Grantee:Julio Cesar Rosa e Silva
Support Opportunities: Regular Research Grants