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Analysis of transcriptional and post-transciptional regulation of estrogen receptor (er) on altered estrogen-mediated effects in the carotid of aging female mice

Grant number: 15/26690-9
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): May 01, 2016
Effective date (End): March 31, 2017
Field of knowledge:Biological Sciences - Pharmacology
Principal Investigator:Maria Helena Catelli de Carvalho
Grantee:Tiago Januário da Costa
Supervisor abroad: Ana Paula Villela Dantas
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Local de pesquisa : Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Spain  
Associated to the scholarship:13/19423-9 - Effects of hormonal treatment with estrogen on carotid function of senescent females: influence of epigenetic regulation, BP.DR

Abstract

The increased risk of cardiovascular diseases in postmenopausal women has been linked to the decrease in plasma estrogen levels. The risk-benefits of estrogen treatment in carried out on aged women, who were on average, 10 years past the onset of postmenopausal women may, in part, be explained by age disparity among studies. The cardiovascular effects of estrogen treatment in experimental studies have been determined mostly in young ovariectomized females, clinical trials have been menopause. Aging, per se, is known to cause a series of alterations in the endogenous mechanisms that control cardiovascular function leading to subsequently increased risk of cardiovascular disease.Studies by our laboratory and clinical trials suggest that part of the vascular opposite effects of estrogen in carotid of SAMR1, young, and SAMP8, aging, female mice. Besides, growing evidence from research studies have described an intimate relationship of increased vasoconstriction prostanoids with vascular dysfunction and increased risk for cardiovascular disease with aging. In this project, we will test the overall hypothesis that late and early estrogen replacement will modulate vascular function in a pharmacologically distinct manner in young and senescent ovariectomized mice and in an estrogen receptor (ERa and ERb)-dependent manner by contribute for this phenomenon. Will test the hypothesis that differential expression and/or activation of estrogen receptor subtypes contributes to differential effects of vascular function early and late estrogen treatment SAMR1 and SAMP8 ovarian deficiency mice.