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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cervical Infection with Cutaneous Beta and Mucosal Alpha Papillomaviruses

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Author(s):
Sichero, Laura [1] ; El-Zein, Mariam [2] ; Nunes, Emily M. [1] ; Ferreira, Silvaneide [1] ; Franco, Eduardo L. [2] ; Villa, Luisa L. [3, 1] ; Study, Ludwig-McGill Cohort
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Med, Hosp Clin, Ctr Translat Invest Oncol, Inst Canc Estado Sao Pa, Sao Paulo - Brazil
[2] McGill Univ, Div Canc Epidemiol, Montreal, PQ - Canada
[3] Univ Sao Paulo, Fac Med, Dept Radiol & Oncol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION; v. 26, n. 8, p. 1312-1320, AUG 2017.
Web of Science Citations: 7
Abstract

Background: Alpha-human papillomavirus (alpha-HPV) plays a causal role in cervical cancer, but little is known about the epidemiology of genital Beta-human papillomavirus (beta-HPV) infection. Methods: We used Luminex and PCR hybridization to detect band alpha-HPVs prevalence at enrollment and 12-month follow-up in cervical samples from 505 women enrolled in the Ludwig-McGill cohort study. We compared epidemiologic correlates of both band alpha-HPVs and compared genotypes between these genera with respect to co-occurrence and association with cervical cytologic abnormalities. Results: Infection with beta-HPV types was more prevalent than that with alpha-HPV types at both visits (cumulative prevalences: 27.3% vs. 21.6%, respectively, P = 0.034). beta-HPVs were mostly transient; however, only 1.98% women retained their original positivity at 12 months, whereas persistence was higher for alpha-HPVs (5.15%; P = 0.007). Age, parity, and sexual activity variables were predictors of alpha-HPV but not of beta-HPV alpha-and beta-HPV types occurred independently. Increased risk of cervical abnormalities was restricted to women infected with alpha-9 or alpha-6 HPV types. We found no epidemiologic correlates for beta-HPV infections. Conclusions: Detection of beta-HPV types in the cervix tends to occur as random and transient episodes not explained via the sexual-transmission correlates that characterize infections by alpha-HPVs. Impact: Although it is plausible that beta-HPVs may play a direct or indirect carcinogenic role, the lack of epidemiologic correlates for detection episodes of these viruses and lack of association with cervical lesions speak against their ancillary role as sexually transmitted agents in cervical carcinogenesis. (C) 2017 AACR. (AU)

FAPESP's process: 08/57889-1 - Institute of Science and Technology to study Diseases Associated with Papillomavirus
Grantee:Luisa Lina Villa
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/20470-1 - Prevalence and diversity of Beta-papillomavirus in anogenital and oral samples of males from the him study
Grantee:Emily Montosa Nunes
Support type: Scholarships in Brazil - Master
FAPESP's process: 13/01440-4 - Prevalence and diversity of Beta-papillomavirus in anogenital and oral samples of males from the him study
Grantee:Laura Cristina Sichero Vettorazzo
Support type: Regular Research Grants