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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anti-apoptotic effects of decyl gallate on the induction of apoptosis in A549 pneumocytes by Paracoccidioides brasiliensis gp43

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Author(s):
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Bernardi, Thais [1] ; da Silva, Julhiany de Fatima [1] ; Vicentin, Juliana [1] ; de Oliveira, Haroldo Cesar [1] ; Assato, Patricia Akemi [1] ; Marcos, Caroline Maria [1] ; Alves de Paula e Silva, Ana Carolina [1] ; Moraes da Silva, Rosangela Aparecida [1] ; Regasini, Luis Octavio [2] ; Siqueira Silva, Dulce Helena [3] ; Bolzani, Vanderlan da Silva [3] ; Fusco-Almeida, Ana Marisa [1] ; Soares Mendes-Giannini, Maria Jose [1]
Total Authors: 13
Affiliation:
[1] Univ Estadual Paulista, UNESP, Fac Ciencias Farmaceut, Dept Anal Clin, Lab Micol Clin, Campus Araraquara, Araraquara, SP - Brazil
[2] Univ Estadual Paulista, UNESP, Inst Biociencias Letras & Ciencias Exatas, Dept Quim & Ciencias Ambientais, Campus Sao Jose Do Rio Preto, Sao Jose Do Rio Preto, SP - Brazil
[3] Univ Estadual Paulista, UNESP, Inst Quim, Dept Quim Organ, Campus Araraquara, Araraquara, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Medical Mycology; v. 55, n. 8, p. 890-894, NOV 2017.
Web of Science Citations: 1
Abstract

Apoptosis is considered an escapemechanism from the host immune system for the fungus Paracoccidioides spp, and it serves as a vehicle for entry into macrophages without stimulating microbicidal activities. Recently, gp43 of P. brasiliensis was demonstrated to be involved in this process. Therefore, as a new therapeutic alternative, it is very important to study compounds that could reduce the modulation of the induction of apoptosis caused by this fungus. Decyl gallate (G14) is a known antifungal compound, and we decided to investigate its anti-apoptotic properties. Our results demonstrate that G14 was effective against apoptosis induced by gp43, as observed in epithelial cells, and led to a reduction in DNA damage, Bak down-regulation and Bcl-2 up-regulation. Together, these data show that G14 presents promising anti-apoptotic activity. (AU)

FAPESP's process: 11/18038-9 - Characterization and functional analysis of the gene for 14-3-3 protein involved in the process of adhesion of Paracoccidioides sp. complex and identification of potential targets in the treatment of paracoccidioidomycosis
Grantee:Maria José Soares Mendes Giannini
Support Opportunities: Regular Research Grants
FAPESP's process: 15/14023-8 - Use of peptides with anti-adhesive activity in Paracoccidoides spp. in the treatment and prophylaxis of the paracoccidioidomycosis
Grantee:Haroldo Cesar de Oliveira
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/17048-4 - Two-component signal transduction (TCST) system as a new target for the treatment of paracoccidioidomycosis
Grantee:Caroline Maria Marcos
Support Opportunities: Scholarships in Brazil - Post-Doctoral