| Full text | |
| Author(s): |
Total Authors: 2
|
| Affiliation: | [1] Emory Univ, Dept Chem, 1515 Dickey Dr, Atlanta, GA 30322 - USA
[2] Univ Estadual Campinas, Inst Chem, Rua Monteiro Lobato 270, Campinas, SP 13083970 - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | ORGANIC LETTERS; v. 19, n. 19, p. 5158-5161, OCT 6 2017. |
| Web of Science Citations: | 13 |
| Abstract | |
Two approaches were developed for the conversion of isoxazol-5-ones to 2,3-dihydro-6H-1,3-oxazin-6-ones. The first involves dirhodium-catalyzed reaction of aryl diazoacetates, leading to rhodium carbene intermediates that undergo insertion into the N-O bond of isoxazol-5-ones. The second approach involves conversion of the aryldiazoacetates to the corresponding tosylates, followed by reaction with the isoxazol-5-one in a metal-free one-pot procedure. These studies illustrate an alternative method to achieve a carbene-like transformation without requiring a metal catalyst. (AU) | |
| FAPESP's process: | 15/20809-4 - Exploring the Chemistry of Isoxazol-5-ones as Versatile Building Blocks in Organic Synthesis |
| Grantee: | Igor Dias Jurberg |
| Support Opportunities: | Regular Research Grants |