Effects of maternal blood gas values corticotherapy of Lambs born at term and premature

Author(s)

Francisco Leydson Formiga Feitosa ^[1] ; Larissa Gabriela Ávila ^[2] ; Fernanda Bovino ^[3] ; Guilherme Gonçalves Fabretti Santos ^[4] ; Luiz Cláudio Nogueira Mendes ^[5] ; Juliana Regina Peiró ^[6] ; Sílvia Helena Venturolli Perri ^[7]

Affiliation

^[1] Universidade Estadual Paulista. Faculdade de Medicina Veterinária. Departamento de Clínica, Cirurgia e Reprodução Animal - Brasil

^[2] Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina Veterinária e Zootecnia - Brasil

^[3] Unesp. Faculdade de Medicina Veterinária - Brasil

^[4] Unesp. Faculdade de Medicina Veterinária - Brasil

^[5] Universidade Estadual Paulista. Faculdade de Medicina Veterinária. Departamento de Clínica, Cirurgia e Reprodução Animal - Brasil

^[6] Universidade Estadual Paulista. Faculdade de Medicina Veterinária. Departamento de Clínica, Cirurgia e Reprodução Animal - Brasil

^[7] Unesp. Faculdade de Medicina Veterinária. Departamento de Apoio à Produção e Saúde Animal - Brasil

• Document type: Journal article
• Source: Pesquisa Veterinária Brasileira; v. 37, n. 5, p. 521-525, 2017-05-00.

Abstract

ABSTRACT: The aim of the study was to evaluate blood gas parameters of full-term and premature lambs from birth to 48 hours of life. Four experimental groups were formed: NDG (normal delivery group - lambs vaginally delivered, n=15, average of 146-day gestation); NDEXG (normal delivery with dexamethasone group - lambs vaginally delivered whose mothers received 16 mg of dexamethasone at 141 days of gestation, n=8, average of 143-day gestation); PRE (premature lambs born by cesarean section at 138 days of gestation, n=10) and PREDEX (premature lambs born by cesarean section at 138 days gestation, whose mothers received 16mg of dexamethasone two days before, n=9). Immediately after birth, lambs from all groups showed respiratory acidosis (low pH and high pCO2), most obviously in premature animals. The concentration of HCO3 - was lower between 15 and 60 minutes of life, especially in PRE and PREDEX groups with subsequent increase in M24h. The values of base excess were lower in premature lambs, which showed abdominal breathing, severe dyspnea and lots of lung fluid. The stabilization of acid-base balance occurred in all animals during the first 24 hours of life. Dexamethasone had a positive effect on the clinical condition of the premature lambs, resulting in adequate ventilation and tissue perfusion, which guaranteed higher survival rate. (AU)

• FAPESP's process: 11/01123-3 - Clinical and laboratorial evaluation of lambs born at term and preterm
• Grantee: Larissa Gabriela Avila
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 10/19497-4 - Clinical and laboratorial evaluation of lambs born at term and preterm
• Grantee: Francisco Leydson Formiga Feitosa
• Support Opportunities: Regular Research Grants