POLYMERSOMES VERSUS LIPOSOMES: THE "MAGIC BULLET" EVOLUTION

Author(s)

Alexsandra Conceição Apolinário ^[1] ; Juliana de Almeida Pachioni-Vasconcelos ^[2] ; Adalberto Pessoa Jr. ^[3] ; Carlota de Oliveira Rangel-Yagui ^[4]

Affiliation

^[1] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Tecnologia Bioquímico-Farmacêutica - Brasil

^[2] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Tecnologia Bioquímico-Farmacêutica - Brasil

^[3] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Tecnologia Bioquímico-Farmacêutica - Brasil

^[4] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Tecnologia Bioquímico-Farmacêutica - Brasil

• Document type: Journal article
• Source: Química Nova; v. 40, n. 7, p. 810-817, 2017-08-00.

Abstract

Polymeric vesicles known as polymersomes are formed by the self-assemble of amphiphilic block copolymers and have structural organization similar to liposomes. However, polymersomes present higher physicochemical stability and structure versatility due to their polymeric nature. In this review we describe the main aspects related to the structure and applications of these systems for drug delivery. (AU)

• FAPESP's process: 14/10456-4 - Development and characterization of poly(ethylene glycol) methyl ether-Block-Poly (D,L-Lactide) (PEG-PLA) Polymersomes for the release of recombinant L-asparaginase
• Grantee: Alexsandra Conceição Apolinário
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 13/08617-7 - Production of extracellular L-asparaginase: from bioprospecting to the engineering of an antileukemic biopharmaceutical
• Grantee: Adalberto Pessoa Junior
• Support Opportunities: Research Projects - Thematic Grants