Effects of photobiomodulation on experimental models of peripheral nerve injury

Author(s)

Andreo, L. ^[1] ; Soldera, C. B. ^[2] ; Ribeiro, B. G. ^[2] ; de Matos, P. R. V. ^[3] ; Bussadori, S. K. ^{[1, 2]} ; Fernandes, K. P. S. ^[1] ; Mesquita-Ferrari, R. A. ^{[1, 2]}

Affiliation

^[1] Univ Nove Julho UNINOVE, Postgrad Program Biophoton Appl Hlth Sci, Rua Vergueiro 349, BR-01504001 Sao Paulo, SP - Brazil

^[2] UNINOVE, Postgrad Program Rehabil Sci, Sao Paulo, SP - Brazil

^[3] UNINOVE, Undergrad Program Phys Therapy, Sao Paulo, SP - Brazil

• Document type: Review article
• Source: Lasers in Medical Science; v. 32, n. 9, p. 2155-2165, DEC 2017.
• Web of Science Citations: 6

Abstract

Phototherapy has demonstrated positive effects in the treatment of peripheral nerve injury, but there is a need to investigate the dosimetric parameters. Thus, the aim of the present study was to conduct a literature review on the effects of photobiomodulation with the use of low-level laser therapy (LLLT) on the treatment of peripheral nerve injury in experimental models. The databases of PubMed/MEDLINE, SCOPUS, and SPIE Digital Library were searched for articles on the use of LLLT in experimental models of peripheral nerve injury published in English between January 2007 and March 2016. The laser parameter variability was wavelength (632.8 to 980 nm), power (10 to 190 mW), and total energy (0.15 to 90 J) in pulsed or continuous wave and single or multiple points. Eighteen original articles demonstrating the effects of LLLT on the acceleration of functional recovery, morphological aspects as well as the modulation of the expression inflammatory cytokines, and growth factors were selected. LLLT is a viable phototherapeutic modality for the treatment of peripheral nerve injury, demonstrating positive effects on the neuromuscular repair process using either red or infrared light. The majority of studies used a power of up to 50 mW and total energy of up to 15 J administered to multiple points. The determination of these parameters is important to the standardization of a LLLT protocol to enhance the regeneration process following a peripheral nerve injury. (AU)

• FAPESP's process: 14/12381-1 - Comparative analysis of the effect of previous laser therapy associated or not to post treatment on the modulation of inflammatory cytokines, oxidative stress and the determination of muscle fiber type after acute injury
• Grantee: Raquel Agnelli Mesquita Ferrari
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/07502-1 - Effect of laser therapy on gene expression and production of cytokines, chemokines and growth factors involved in muscle repair
• Grantee: Kristianne Porta Santos Fernandes
• Support Opportunities: Regular Research Grants