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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Alternagin-C (ALT-C), a Disintegrin-Like Cys-Rich Protein Isolated from the Venom of the Snake Rhinocerophis alternatus, Stimulates Angiogenesis and Antioxidant Defenses in the Liver of Freshwater Fish, Hoplias malabaricus

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Author(s):
Monteiro, Diana Amaral [1] ; Selistre-de-Araujo, Heloisa Sobreiro [1] ; Tavares, Driele [1] ; Fernandes, Marisa Narciso [1] ; Kalinin, Ana Lucia [1] ; Rantin, Francisco Tadeu [1]
Total Authors: 6
Affiliation:
[1] Fed Univ Sao Carlos UFSCar, Dept Physiol Sci, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: TOXINS; v. 9, n. 10 OCT 2017.
Web of Science Citations: 2
Abstract

Alternagin-C (ALT-C) is a disintegrin-like protein isolated from Rhinocerophis alternatus snake venom, which induces endothelial cell proliferation and angiogenesis. The aim of this study was to evaluate the systemic effects of a single dose of alternagin-C (0.5 mg<bold>kg</bold>-1, via intra-arterial) on oxidative stress biomarkers, histological alterations, vascular endothelial growth factor (VEGF) production, and the degree of vascularization in the liver of the freshwater fish traira, Hoplias malabaricus, seven days after the initiation of therapy. ALT-C treatment increased VEGF levels and hepatic angiogenesis. ALT-C also enhanced hepatic antioxidant enzymes activities such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase, decreasing the basal oxidative damage to lipids and proteins in the fish liver. These results indicate that ALT-C improved hepatic tissue and may play a crucial role in tissue regeneration mechanisms. (AU)

FAPESP's process: 13/00798-2 - The extracellular matrix in aging, exercise and in the tumor microenvironment
Grantee:Heloisa Sobreiro Selistre de Araújo
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 12/10993-4 - Effects of alternagin-C (ALT-C), a protein from venom of urutu snake (Rhinocerophis alternatus, previously known Bothrops alternatus), on fish cardiac contractility under normoxia and against tissue hypoxia
Grantee:Diana Amaral Monteiro
Support Opportunities: Scholarships in Brazil - Post-Doctoral