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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Abnormal carbohydrate metabolism in a canine model for muscular dystrophy

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Amaral, Andressa R. [1] ; Brunetto, Marcio A. [2] ; Brolio, Marina P. [3] ; Cima, Daniela S. [4] ; Miglino, Maria A. [3] ; Santos, Joao Paulo F. [2] ; Ambrosio, Carlos E. [1]
Total Authors: 7
[1] Univ Sao Paulo, Vet Med Dept, Fac Anim Sci & Food Engn FZEA, Ave Duque Caxias Norte 225, BR-13635900 Pirassununga, SP - Brazil
[2] Univ Sao Paulo, Anim Nutr & Prod Dept, Fac Vet Med & Anim Sci FMVZ, Ave Duque Caxias Norte 225, BR-13635900 Pirassununga, SP - Brazil
[3] Univ Sao Paulo, Fac Vet Med & Anim Sci FMVZ, Surg Dept, Ave Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP - Brazil
[4] Univ Guarulhos, Vet Anesthesiol Dept, Anton Philips St 1, BR-07030010 Guarulhos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 0

The canine golden retriever muscular dystrophy (GRMD) model is the best animal model for studying Duchenne muscular dystrophy in humans. Considering the importance of glucose metabolism in the muscles, the existence of metabolic and endocrine alterations in a wide range of muscular dystrophies, and the pre-existing relationship between blood insulin concentration and muscular atrophy, the present study aimed to evaluate the postprandial glucose and insulin response in GRMD dogs. A total of eighteen golden retriever dogs were randomly distributed into three experimental groups: healthy/control (G1), female GRMD carriers (G2), and male dogs affected by GRMD (G3). Higher plasma resting glucose levels (P = 0.0047) were seen in G2 and G3 compared with G1, as was the case for minimum (P = <0.0001), mean (P = 0.0002) and maximum (P = 0.0359) glucose values for G3 compared with G1. Fructosamine concentrations were in accordance with reference values found in the literature for dogs. Insulin levels were lower in G3 compared with G1 (P = 0.0065); however, there was no evidence of insulin resistance according to the homeostasis model assessment index values obtained. As for the evaluation of postprandial responses, fluctuations of glucose (P = 0.0007) and insulin (P = 0.0149) were observed in G1 and G2, while in G3 the values remained constant. The results allowed us to identify metabolic changes related to carbohydrate metabolism in GRMD dogs, highlighting the importance of adequate food management for these animals. (AU)

FAPESP's process: 13/01191-4 - Evaluation of carbohydrate metabolism of Golden retriever dogs, carriers and affected, by progressive muscular dystrophy (GRMD)
Grantee:Andressa Rodrigues Amaral
Support type: Scholarships in Brazil - Scientific Initiation